ArticleThe American journal of pathology1999
Demonstration of urokinase expression in cancer cells of colon adenocarcinomas by immunohistochemistry and in situ hybridization.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 48 citations in OpenAlex.
- Comprehensive analysis of ceRNA networks reveals prognostic lncRNAs related to immune infiltration in colorectal cancer.BMC cancer · 2021Article
- Usefulness of plasma D-dimer level for monitoring development of distant organ metastasis in colorectal cancer patients after curative resection.Cancer management and research · 2018Article
- High level of urokinase plasminogen activator contributes to cholangiocarcinoma invasion and metastasis.World journal of gastroenterology · 2012Article
- Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade.PloS one · 2012Article
- The tumor microenvironment in colorectal carcinogenesis.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2010Article
- Bacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-kappaB-dependent activation of the urokinase plasminogen activator system.British journal of cancer · 2009Article
- A pilot study of urokinase-type plasminogen activator (uPA) overexpression in the brush cytology of patients with malignant pancreatic or biliary strictures.HPB surgery : a world journal of hepatic, pancreatic and biliary surgery · 2009Article
- Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer.BMC cancer · 2006Article
- Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis.The American journal of pathology · 2000Article
- The hemostatic system and angiogenesis in malignancy.Neoplasia (New York, N.Y.)Review
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
The question whether urokinase is expressed in human colon cancer by the cancer cells themselves or by surrounding stromal elements such as fibroblasts, macrophages, and leukocytes, which transfer the activator to the receptors of the cancer cells, has been a controversial one. In the present study 12 cases of colorectal cancer were investigated by immunohistochemical methods using three monoclonal antibodies of different specificity against urokinase. Cytoplasmic staining of strongly varying intensity was observed in all cases, with the antigen expressed most strongly in the apical and the basal regions of the cancer cells. In some cases, staining was also found in stromal elements surrounding the cancer glands. That the activator was indeed the product of the cancer cells was demonstrated by in situ hybridization using a uPA-cDNA probe, which detected the presence of uPA-mRNA in both the basal and the apical regions of the cancer cells. A monoclonal antibody against the receptor for uPA showed similar localization. These findings indicate that the activator is expressed by the cancer cells and is not recruited by them from stromal elements.
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