Evidence map›Paper›PMID 10514160›Full record

Trial reportBMJ (Clinical research ed.)1999

Pragmatic randomised controlled trial of local corticosteroid injection and naproxen for treatment of lateral epicondylitis of elbow in primary care.

E M Hay, S M Paterson, M Lewis, G Hosie, P Croft

Registry-linked trialOpen access · bronzeAbstract readClinical TrialMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00110318 (A Pragmatic, Randomised Controlled Trial of Physiotherapy and Corticosteroid Injections in Lateral Epicondylalgia), which is not on this map. Cited by 68 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 12 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00110318 phase3completednot on this mapstarted 2002, after this paper: background citation

A Pragmatic, Randomised Controlled Trial of Physiotherapy and Corticosteroid Injections in Lateral Epicondylalgia

TypeinterventionalSponsorThe University of QueenslandRan2002 to 2006Enrolled198ConditionsTennis Elbow, Musculoskeletal DiseasesArmsManual therapy and therapeutic exercise, Corticosteroid injections
3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 12 syntheses or guidelines pooled it, 307 citations in OpenAlex.

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  5. Tennis elbow.BMJ clinical evidence · 2011
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  9. Tennis elbow.BMJ clinical evidence · 2008
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

E M HayStaffordshire Rheumatology Centre, The Haywood, Burslem, Stoke on Trent ST6 7AG. Pra19@keele.ac.uk
S M Paterson
M Lewis
G Hosie
P Croft
Keele University · GBHaywood Community Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the clinical effectiveness of local corticosteroid injection, standard non-steroidal anti-inflammatory drugs, and simple analgesics for the early treatment of lateral epicondylitis in primary care.

designMulticentre pragmatic randomised controlled trial.

setting23 general practices in North Staffordshire and South Cheshire.

participants164 patients aged 18-70 years presenting with a new episode of lateral epicondylitis.

interventionsLocal injection of 20 mg methylprednisolone plus lignocaine, naproxen 500 mg twice daily for two weeks, or placebo tablets. All participants received a standard advice sheet and co-codamol as required.

main outcome measuresParticipants' global assessment of improvement (five point scale) at four weeks. Pain, function, and "main complaint" measured on 10 point Likert scales at 4 weeks, 6 months, and 12 months.

resultsOver 2 years, 53 subjects were randomised to injection, 53 to naproxen, and 58 to placebo. Prognostic variables were similar between groups at baseline. At 4 weeks, 48 patients (92%) in the injection group were completely better or improved compared with 30 (57%) in the naproxen group (P<0.001) and 28 (50%) in the placebo group (P<0.001). At 12 months, 43 patients (84%) in the injection group had pain scores </=3 compared with 45 (85%) in the naproxen group and 44 (82%) in the placebo group (P>0.05).

conclusionsEarly local corticosteroid injection is effective for lateral epicondylitis. Outcome at one year was good in all groups, and effective early treatment does not seem to influence this.

Indexed as

AdolescentAdultAgedAnti-Inflammatory Agents, Non-SteroidalDrug CombinationsFemaleHumansInjections, IntramuscularInjections, SubcutaneousMaleMethylprednisoloneMiddle AgedNaproxenTennis ElbowTreatment OutcomeAnti-Inflammatory Agents, Non-SteroidalDrug CombinationsMethylprednisoloneNaproxen

Identifiers

PMID10514160
PMCPMC28251
OpenAlexW2007928389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.