ReviewDrug safety1999
Risk-benefit assessment of opioids in chronic noncancer pain.
Review in Drug safety, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 87 citations in OpenAlex.
- Efficacy and safety of Tapentadol extended release compared with oxycodone controlled release for the management of moderate to severe chronic pain related to osteoarthritis of the knee: a randomized, double-blind, placebo- and active-controlled phase III study.Clinical drug investigation · 2010Trial
- Trial
- Hybrid Statistical and Mechanistic Mathematical Model Guides Mobile Health Intervention for Chronic Pain.Journal of computational biology : a journal of computational molecular cell biology · 2017Article
- Effect of long-term treatment of morphine on enzymes, oxidative stress indices and antioxidant status in male rat liver.International journal of clinical and experimental medicine · 2014Article
- Antioxidant effects of some drugs on immobilization stress combined with cold restraint stress.Molecules (Basel, Switzerland) · 2009Article
- The use of opioids in the treatment of osteoarthritis: when, why, and how?Current rheumatology reports · 2009Review
- Drug-induced musculoskeletal disorders.Drug safety · 2007Review
- The use of opioids in the treatment of osteoarthritis: when, why, and how?Current pain and headache reports · 2005Review
- Liver and kidney toxicity in chronic use of opioids: an experimental long term treatment model.Journal of biosciences · 2005Article
- Chronic non-cancer pain and opioid dependence.Journal of the Royal Society of Medicine · 2004Review
- Pain management in older adults.Current psychiatry reports · 2003Review
- Benefit-risk assessment of transdermal fentanyl for the treatment of chronic pain.Drug safety · 2003Review
- Transdermal buprenorphine.Drugs · 2003Review
- The assessment and management of chronic pain in children.Paediatric drugs · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Opioids have been accepted as appropriate treatment for acute and cancer pain, but their role in the management of chronic nonmalignant pain is the subject of much debate, mainly due to concerns about waning efficacy, the potential for neuropsychological impairment and the development of drug addiction. Controlled clinical trials demonstrated that opioids may be effective in both nociceptive and neuropathic noncancer pain, although the former responded more consistently than the latter. Gastrointestinal and CNS adverse effects were frequent in most studies. Observational studies have generated contradictory findings regarding efficacy and safety as well as the risk of drug addiction in patients with chronic noncancer pain receiving long term opioid therapy. However, they suggest that opioids may be effective in individual cases, whichever the pathophysiological mechanism of pain. Taken together, the available data indicate that the outcomes associated with opioid therapy vary markedly across patients experiencing chronic nonmalignant pain. The main consensus is that a subset of these patients may gain substantial benefit from opioid analgesics without requiring rapidly escalating doses or developing intolerable adverse effects or drug addiction. Prescribing guidelines have been developed to assist practitioners in selecting the appropriate patients and ensuring an acceptable risk : benefit ratio of opioid therapy. Finally, it must be emphasised that chronic pain is a complex entity wherein analgesics, including opioids, are only part of the treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.