Are drugs within a class interchangeable?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

26 citing papers in PubMed.

1. Failures in a proton pump inhibitor therapeutic substitution program: lessons learned.Digestive diseases and sciences · 2007
   Trial
2. Composite endpoints in health technology assessment: Part 2 - expanding the evidence base with a framework for best modeling practice.Journal of comparative effectiveness research · 2025
   Article
3. Use of progestogens and the risk of intracranial meningioma: national case-control study.BMJ (Clinical research ed.) · 2024
   Article
4. Key concepts for informed health choices. 1.2: Seemingly logical assumptions about research can be misleading.Journal of the Royal Society of Medicine · 2022
   Article
5. Long-Term Effect of Non-Selective Beta-Blockers in Patients With Rheumatoid Arthritis After Myocardial Infarction-A Nationwide Cohort Study.Frontiers in pharmacology · 2021
   Article
6. Liver Protective Effects of Renin-Angiotensin System Inhibition Have No Survival Benefits in Hepatocellular Carcinoma Induced By Repetitive Administration of Diethylnitrosamine in Mice.Open access Macedonian journal of medical sciences · 2018
   Article
7. Class effect of beta-blockers in survivors of ST-elevation myocardial infarction: A nationwide cohort study using an insurance claims database.Scientific reports · 2015
   Article
8. Development and evaluation of a computerised clinical decision support system for switching drugs at the interface between primary and tertiary care.BMC medical informatics and decision making · 2012
   Article
9. Trends in use of second-generation antipsychotics for treatment of bipolar disorder in the United States, 1998-2009.Psychiatric services (Washington, D.C.) · 2012
   Article
10. Increasing off-label use of antipsychotic medications in the United States, 1995-2008.Pharmacoepidemiology and drug safety · 2011
    Article
11. Do ACE inhibitors all provide the same outcomes benefits in high-risk cardiovascular patients?Current hypertension reports · 2008
    Review
12. Dihydropyridine calcium channel blockers and cardiovascular outcomes in elderly patients: a population-based study.The Canadian journal of cardiology · 2008
    Article
13. Rule-based standardised switching of drugs at the interface between primary and tertiary care.European journal of clinical pharmacology · 2008
    Article
14. Society already achieves economic benefits from generic substitution but fails to do the same for therapeutic substitution.British journal of clinical pharmacology · 2007
    Article
15. Statins in elderly patients with acute coronary syndrome: an analysis of dose and class effects in typical practice.Heart (British Cardiac Society) · 2007
    Article
16. A composite screening tool for medication reviews of outpatients: general issues with specific examples.Drugs & aging · 2007
    Review
17. Class effects and labeling of antihypertensive drugs.Journal of clinical hypertension (Greenwich, Conn.) · 2006
    Review
18. Statins research unfinished saga: desirability versus feasibility.Cardiovascular diabetology · 2005
    Article
19. Effectiveness of statins for secondary prevention in elderly patients after acute myocardial infarction: an evaluation of class effect.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2005
    Article
20. Current trends in the cardiovascular clinical trial arena (I).Current controlled trials in cardiovascular medicine · 2004
    Article

Corrections and comments

• Commented on by
  Are drugs interchangeable?2000
• Commented on by
  Are drugs interchangeable?2000
• Commented on by
  Are drugs interchangeable?2000
• Commented on by
  First-line antihypertensive therapy.2000

Authors and funding

3 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as