ArticleMolecular biology of the cell1999
Integrin-mediated adhesion of endothelial cells induces JAK2 and STAT5A activation: role in the control of c-fos gene expression.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
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- The Human Tissue-Engineered Cornea (hTEC): Recent Progress.International journal of molecular sciences · 2021Review
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- Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner.Experimental cell research · 2011Article
- Prolactin receptor-integrin cross-talk mediated by SIRPα in breast cancer cells.Molecular cancer research : MCR · 2010Article
- Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis.The Journal of biological chemistry · 2009Article
- Substance P mediates antiapoptotic responses in human colonocytes by Akt activation.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration.Molecular biology of the cell · 2006Article
- STAT 5a expression in various lesions of the breast.Virchows Archiv : an international journal of pathology · 2006Article
- {beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation.The Journal of cell biology · 2005Article
- Chromatin acetylation and remodeling at the Cis promoter during STAT5-induced transcription.Nucleic acids research · 2003Article
- TGFbeta1 activates c-Jun and Erk1 via alphaVbeta6 integrin.Molecular cancer · 2003Article
- Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important for angiogenesis and inflammation.Molecular and cellular biology · 2002Article
- Diabetic LDL inhibits cell-cycle progression via STAT5B and p21(waf).The Journal of clinical investigation · 2002Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integrin-mediated adhesion induces several signaling pathways leading to regulation of gene transcription, control of cell cycle entry and survival from apoptosis. Here we investigate the involvement of the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway in integrin-mediated signaling. Plating primary human endothelial cells from umbilical cord and the human endothelial cell line ECV304 on matrix proteins or on antibody to beta1- or alphav-integrin subunits induces transient tyrosine phosphorylation of JAK2 and STAT5A. Consistent with a role for the JAK/STAT pathway in regulation of gene transcription, adhesion to matrix proteins leads to the formation of STAT5A-containing complexes with the serum-inducible element of c-fos promoter. Stable expression of a dominant negative form of STAT5A in NIH3T3 cells reduces fibronectin-induced c-fos mRNA expression, indicating the involvement of STAT5A in integrin-mediated c-fos transcription. Thus these data present a new integrin-dependent signaling mechanism involving the JAK/STAT pathway in response to cell-matrix interaction.
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