ArticleMolecular biology of the cell1999
The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 70 citations in OpenAlex.
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- Research Progress on the Mechanism and Function of Histone Acetylation Regulating the Interaction between Pathogenic Fungi and Plant Hosts.Journal of fungi (Basel, Switzerland) · 2024Review
- Systematic characterization ofFrontiers in microbiology · 2023Article
- Sirtuins are Not Conserved Longevity Genes.Life metabolism · 2022Article
- Histone acetylation dynamics in repair of DNA double-strand breaks.Frontiers in genetics · 2022Review
- Fission Yeast Sirtuin Hst4 Functions in Preserving Genomic Integrity by Regulating Replisome Component Mcl1.Scientific reports · 2018Article
- A Matter of Scale and Dimensions: Chromatin of Chromosome Landmarks in the Fungi.Microbiology spectrum · 2017Review
- A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave.Cell cycle (Georgetown, Tex.) · 2016Article
- Silencing is noisy: population and cell level noise in telomere-adjacent genes is dependent on telomere position and sir2.PLoS genetics · 2014Article
- Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast.The EMBO journal · 2013Article
- The role of MutY homolog (Myh1) in controlling the histone deacetylase Hst4 in the fission yeast Schizosaccharomyces pombe.Journal of molecular biology · 2011Article
- HST3/HST4-dependent deacetylation of lysine 56 of histone H3 in silent chromatin.Molecular biology of the cell · 2008Article
- A DNA polymerase alpha accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast.PloS one · 2008Article
- Schizosaccharomyces pombe Hst4 functions in DNA damage response by regulating histone H3 K56 acetylation.Eukaryotic cell · 2008Article
- Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing.The EMBO journal · 2007Article
- Individual subunits of the Ssn6-Tup11/12 corepressor are selectively required for repression of different target genes.Molecular and cellular biology · 2007Article
- Article
- BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere.Molecular biology of the cell · 2005Article
- A high proportion of genes involved in position effect variegation also affect chromosome inheritance.Chromosoma · 2004Article
- Fission yeast Arp6 is required for telomere silencing, but functions independently of Swi6.Nucleic acids research · 2004Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although silencing is a significant form of transcriptional regulation, the functional and mechanistic limits of its conservation have not yet been established. We have identified the Schizosaccharomyces pombe hst4(+) gene as a member of the SIR2/HST silencing gene family that is defined in organisms ranging from bacteria to humans. hst4Delta mutants grow more slowly than wild-type cells and have abnormal morphology and fragmented DNA. Mutant strains show decreased silencing of reporter genes at both telomeres and centromeres. hst4(+) appears to be important for centromere function as well because mutants have elevated chromosome-loss rates and are sensitive to a microtubule-destabilizing drug. Consistent with a role in chromatin structure, Hst4p localizes to the nucleus and appears concentrated in the nucleolus. hst4Delta mutant phenotypes, including growth and silencing phenotypes, are similar to those of the Saccharomyces cerevisiae HSTs, and at a molecular level, hst4(+) is most similar to HST4. Furthermore, hst4(+) is a functional homologue of S. cerevisiae HST3 and HST4 in that overexpression of hst4(+) rescues the temperature-sensitivity and telomeric silencing defects of an hst3Delta hst4Delta double mutant. These results together demonstrate that a SIR-like silencing mechanism is conserved in the distantly related yeasts and is likely to be found in other organisms from prokaryotes to mammals.
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