ArticleBiophysical journal1999
Adhesion-induced receptor segregation and adhesion plaque formation: A model membrane study.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 139 citations in OpenAlex.
- Principles and Applications of Biological Membrane Organization.Annual review of biophysics · 2020Review
- Membrane Adhesion via Glycolipids Occurs for Abundant Saccharide Chemistries.Biophysical journal · 2020Article
- Optical tweezers system for live stem cell organization at the single-cell level.Biomedical optics express · 2018Article
- Lectin-mediated protocell crosslinking to mimic cell-cell junctions and adhesion.Scientific reports · 2018Article
- Binding equilibrium and kinetics of membrane-anchored receptors and ligands in cell adhesion: Insights from computational model systems and theory.Cell adhesion & migration · 2016Review
- Continuity of Monolayer-Bilayer Junctions for Localization of Lipid Raft Microdomains in Model Membranes.Scientific reports · 2016Article
- Membrane adhesion and the formation of heterogeneities: biology, biophysics, and biotechnology.Physical chemistry chemical physics : PCCP · 2015Review
- The equilibria of vesicles adhered to substrates by short-ranged potentials.Proceedings. Mathematical, physical, and engineering sciences · 2013Article
- Cell differentiation of pluripotent tissue sheets immobilized on supported membranes displaying cadherin-11.PloS one · 2013Article
- Hematocrit and flow rate regulate the adhesion of platelets to von Willebrand factor.Biomicrofluidics · 2013Article
- Regulation of cell adhesion strength by peripheral focal adhesion distribution.Biophysical journal · 2011Article
- Effects of Membrane Rheology on Leuko-polymersome Adhesion to Inflammatory Ligands.Soft matter · 2011Article
- Entropy-driven aggregation of adhesion sites of supported membranes.The European physical journal. E, Soft matter · 2010Article
- Article
- Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate.PLoS computational biology · 2009Article
- Supported double membranes.Journal of structural biology · 2009Article
- Quantification of nano-scale intermembrane contact areas by using fluorescence resonance energy transfer.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Modulation of vesicle adhesion and spreading kinetics by hyaluronan cushions.Biophysical journal · 2007Article
- Spreading of neutrophils: from activation to migration.Biophysical journal · 2006Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A model system to study the control of cell adhesion by receptor-mediated specific forces, universal interactions, and membrane elasticity is established. The plasma membrane is mimicked by reconstitution of homophilic receptor proteins into solid supported membranes and, together with lipopolymers, into giant vesicles with the polymers forming an artificial glycocalix. The homophilic cell adhesion molecule contact site A, a lipid-anchored glycoprotein from cells of the slime mold Dictyostelium discoideum, is used as receptor. The success of the reconstitution, the structure and the dynamics of the model membranes are studied by various techniques including film balance techniques, micro fluorescence, fluorescence recovery after photobleaching, electron microscopy, and phase contrast microscopy. The interaction of the functionalized giant vesicles with the supported bilayer is studied by reflection interference contrast microscopy, and the adhesion strength is evaluated quantitatively by a recently developed technique. At low receptor concentrations adhesion-induced receptor segregation in the membranes leads to decomposition of the contact zone between membranes into domains of strong (receptor-mediated) adhesion and regions of weak adhesion while continuous zones of strong adhesion form at high receptor densities. The adhesion strengths (measured in terms of the spreading pressure S) of the various states of adhesion are obtained locally by analysis of the vesicle contour near the contact line in terms of elastic boundary conditions of adhesion: the balance of tensions and moments. The spreading pressure of the weak adhesion zones is S approximately 10(-9) J/m(2) and is determined by the interplay of gravitation and undulation forces whereas the spreading pressure of the tight adhesion domains is of the order S approximately 10(-6) J/m(2).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.