ArticleBiophysical journal1999
Voltage-dependent sodium channel function is regulated through membrane mechanics.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 89 citations in OpenAlex.
- A statistical damage model for coupled mechano-electrophysiological axonal injury.PLoS computational biology · 2026Article
- Review
- Saxitoxin: A Comprehensive Review of Its History, Structure, Toxicology, Biosynthesis, Detection, and Preventive Implications.Marine drugs · 2025Review
- Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Mechanisms of Traumatic Spinal Cord Injury AIS Grade Conversion.Neurotrauma reports · 2025Review
- Dissection of the structure-function relationship of NaProceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Voltage-Gated Sodium Channel ineNeuro · 2023Article
- Roles of stretch-activated channels and NADPH oxidase 2 in the induction of twitch contraction by muscle stretching in rat ventricular muscle.Pflugers Archiv : European journal of physiology · 2022Article
- Mechanosensation in traumatic brain injury.Neurobiology of disease · 2021Review
- β1 and β3 subunits amplify mechanosensitivity of the cardiac voltage-gated sodium channel Nav1.5.Pflugers Archiv : European journal of physiology · 2019Article
- Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways.Toxins · 2019Review
- A review on ultrasonic neuromodulation of the peripheral nervous system: enhanced or suppressed activities?Applied sciences (Basel, Switzerland) · 2019Article
- β1 subunit stabilises sodium channel Nav1.7 against mechanical stress.The Journal of physiology · 2018Article
- Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.British journal of pharmacology · 2017Article
- Biophysical implications of lipid bilayer rheometry for mechanosensitive channels.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Stiffened lipid platforms at molecular force foci.Proceedings of the National Academy of Sciences of the United States of America · 2013Review
- Altered sodium channel-protein associations in critical illness myopathy.Skeletal muscle · 2012Article
- Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Repetitive activity slows axonal conduction velocity and concomitantly increases mechanical activation threshold in single axons of the rat cranial dura.The Journal of physiology · 2012Article
- Altered calcium signaling following traumatic brain injury.Frontiers in pharmacology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Cut-open recordings from Xenopus oocytes expressing either nerve (PN1) or skeletal muscle (SkM1) Na(+) channel alpha subunits revealed slow inactivation onset and recovery kinetics of inward current. In contrast, recordings using the macropatch configuration resulted in an immediate negative shift in the voltage-dependence of inactivation and activation, as well as time-dependent shifts in kinetics when compared to cut-open recordings. Specifically, a slow transition from predominantly slow onset and recovery to exclusively fast onset and fast recovery from inactivation occurred. The shift to fast inactivation was accelerated by patch excision and by agents that disrupted microtubule formation. Application of positive pressure to cell-attached macropatch electrodes prevented the shift in kinetics, while negative pressure led to an abrupt shift to fast inactivation. Simultaneous electrophysiological recording and video imaging of the cell-attached patch membrane revealed that the pressure-induced shift to fast inactivation coincided with rupture of sites of membrane attachment to cytoskeleton. These findings raise the possibility that the negative shift in voltage-dependence and the fast kinetics observed normally for endogenous Na(+) channels involve mechanical destabilization. Our observation that the beta1 subunit causes similar changes in function of the Na(+) channel alpha subunit suggests that beta1 may act through interaction with cytoskeleton.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.