ArticleBiophysical journal1999
Does Ca2+ reach millimolar concentrations after single photon absorption in Drosophila photoreceptor microvilli?
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Light adaptation of the microvillus refractory period in blow fly photoreceptors.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- The Role of Membrane Lipids in Light-Activation ofBiomolecules · 2022Review
- A biomimetic fly photoreceptor model elucidates how stochastic adaptive quantal sampling provides a large dynamic range.The Journal of physiology · 2017Review
- Calcium signalling in Drosophila photoreceptors measured with GCaMP6f.Cell calcium · 2017Article
- Insect photoreceptor adaptations to night vision.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Functional cooperation between the IP3 receptor and phospholipase C secures the high sensitivity to light of Drosophila photoreceptors in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Fractional Ca(2+) currents through TRP and TRPL channels in Drosophila photoreceptors.Biophysical journal · 2013Article
- Article
- Phototransduction and retinal degeneration in Drosophila.Pflugers Archiv : European journal of physiology · 2007Review
- Calnexin is essential for rhodopsin maturation, Ca2+ regulation, and photoreceptor cell survival.Neuron · 2006Article
- Light dependence of oxygen consumption by blowfly eyes recorded with a magnetic diver balance.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2005Article
- Light adaptation in Drosophila photoreceptors: II. Rising temperature increases the bandwidth of reliable signaling.The Journal of general physiology · 2001Article
- Calcium imaging demonstrates colocalization of calcium influx and extrusion in fly photoreceptors.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Calcium transients in the rhabdomeres of dark- and light-adapted fly photoreceptor cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The quantum bump, the elementary event of fly phototransduction induced by the absorption of a single photon, is a small, transient current due to the opening of cation-channels permeable to Ca2+. These channels are located in small, tube-like protrusions of the cell membrane, the microvilli. Using a modeling approach, we calculate the changes of free Ca2+ concentration inside the microvilli, taking into account influx and diffusion of Ca2+. Independent of permeability ratios and Ca2+ buffering, we find that the free Ca2+ concentrations rise to millimolar values, as long as we assume that all activated channels are located in a single microvillus. When we assume that as much as 25 microvilli participate in a single bump, the free Ca2+ concentration still reaches values higher than 80 microM. These very high concentrations show that the microvilli of fly photoreceptors are unique structures in which the Ca2+ signaling is even more extreme than in calcium concentration microdomains very close to Ca2+ channels.
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