ArticleAJNR. American journal of neuroradiology1999
Proton MR spectroscopy for the evaluation of brain injury in asphyxiated, term neonates.
Article in AJNR. American journal of neuroradiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 205 citations in OpenAlex.
- Brain proton magnetic resonance spectroscopy and neurodevelopment after preterm birth: a systematic review.Pediatric research · 2022Pooled it
- Brain MR imaging and spectroscopy for outcome prognostication after pediatric cardiac arrest.Resuscitation · 2020Trial
- The Role of Proton Magnetic Resonance Spectroscopy in Neonatal and Fetal Brain Research.Journal of magnetic resonance imaging : JMRI · 2025Review
- Microstructural Alterations in Projection and Association Fibers in Neonatal Hypoxia-Ischemia.Journal of magnetic resonance imaging : JMRI · 2023Article
- Use of Magnetic Resonance Imaging in Neuroprognostication After Pediatric Cardiac Arrest: Survey of Current Practices.Pediatric neurology · 2022Article
- Proton MR Spectroscopy of Pediatric Brain Disorders.Diagnostics (Basel, Switzerland) · 2022Review
- Magnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy.Diagnostics (Basel, Switzerland) · 2022Review
- Lactylation may be a Novel Posttranslational Modification in Inflammation in Neonatal Hypoxic-Ischemic Encephalopathy.Frontiers in pharmacology · 2022Review
- Article
- MR spectroscopy in pediatric neuroradiology.Translational pediatrics · 2021Review
- Epinephrine's effects on cerebrovascular and systemic hemodynamics during cardiopulmonary resuscitation.Critical care (London, England) · 2020Article
- A pictorial review of the pathophysiology and classification of the magnetic resonance imaging patterns of perinatal term hypoxic ischemic brain injury - What the radiologist needs to know….SA journal of radiology · 2020Review
- A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites.Journal of visualized experiments : JoVE · 2018Article
- Assessing Cerebral Metabolism in the Immature Rodent: From Extracts to Real-Time Assessments.Developmental neuroscience · 2018Review
- Complex spatial and temporally defined myelin and axonal degeneration in Huntington disease.NeuroImage. Clinical · 2018Article
- Detection and assessment of brain injury in the growth-restricted fetus and neonate.Pediatric research · 2017Review
- Early identification of hypoxic-ischemic encephalopathy by combination of magnetic resonance (MR) imaging and proton MR spectroscopy.Experimental and therapeutic medicine · 2016Article
- In vivo longitudinal proton magnetic resonance spectroscopy on neonatal hypoxic-ischemic rat brain injury: Neuroprotective effects of acetyl-L-carnitine.Magnetic resonance in medicine · 2015Article
- Proton magnetic resonance spectroscopy and outcome in term neonates with chorioamnionitis.Journal of perinatology : official journal of the California Perinatal Association · 2015Article
- Magnetic Resonance Biomarkers in Neonatal Encephalopathy (MARBLE): a prospective multicountry study.BMJ open · 2015Observational
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeNeurologic and developmental outcomes of asphyxiated, term neonates are difficult to predict applying clinical or laboratory criteria. In this study, we investigated the association of MR spectroscopy (MRS) results with neurodevelopmental status at age 12 months.
methodThirty-one term neonates, who were enrolled in a prospective study of the utility of MR imaging for the determination of neurologic and developmental status, underwent single-voxel proton MRS of the basal nuclei and intervascular boundary zones. Ratios of lactate, choline, creatine, and N-acetylaspartate (NAA) peaks were calculated and tested for association with neuromotor scores and Mental Development Index of the Bayley Scores of Infant Development obtained at age 12 months.
resultsElevated lactate and diminished NAA were the most common findings in infants with neurologic and developmental abnormalities at age 12 months. Although many ratios had statistically significant associations with outcome (P<.05), the highest significance was obtained with lactate/choline ratios in the basal nuclei. A false-positive finding was seen in a patient who was born after a 36-week gestation period (high lactate/choline but normal neurodevelopmental status at 12 months) and in three patients with apparent watershed injury (high watershed lactate/choline but normal neurodevelopmental status at 12 months). A false-negative MRS finding (normal lactate/choline but abnormal outcome) was seen in a patient who had an apparent prenatal injury.
conclusionProton MRS appears to be a useful tool for assessing brain injury in neonates who have suffered hypoxia or ischemia. Correlation with gestational age and imaging findings are essential for proper interpretation of the spectra. Patients with apparent watershed injuries may have normal neurodevelopmental status at age 12 months.
Indexed as
Identifiers
10512219PMC7657756W2169742975What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.