ArticleGenetics1999
The molecular genetics of red and green color vision in mammals.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 121 citations in OpenAlex.
- Parallel Spectral Tuning of a Cone Visual Pigment Provides Evidence for Ancient Deep-Sea Adaptations in Cetaceans.Genome biology and evolution · 2024Article
- Influence of colour vision on attention to, and impression of, complex aesthetic images.Proceedings. Biological sciences · 2023Article
- Diversified Mammalian Visuasl Adaptations to Bright- or Dim-Light Environments.Molecular biology and evolution · 2023Article
- The evolutionary history and spectral tuning of vertebrate visual opsins.Developmental biology · 2023Review
- Making a bat: The developmental basis of bat evolution.Genetics and molecular biology · 2021Article
- Visual adaptation of opsin genes to the aquatic environment in sea snakes.BMC evolutionary biology · 2020Article
- A two-step method for identifying photopigment opsin andMolecular vision · 2020Article
- Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Diversification of spatiotemporal expression and copy number variation of the echinoid hbox12/pmar1/micro1 multigene family.PloS one · 2017Article
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- Digital genotyping of macrosatellites and multicopy genes reveals novel biological functions associated with copy number variation of large tandem repeats.PLoS genetics · 2014Article
- Evolutionary renovation of L/M opsin polymorphism confers a fruit discrimination advantage to ateline New World monkeys.Molecular ecology · 2014Article
- Receptive field properties of color opponent neurons in the cat lateral geniculate nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Gene conversion and purifying selection shape nucleotide variation in gibbon L/M opsin genes.BMC evolutionary biology · 2011Article
- The opsin repertoire of Jenynsia onca: a new perspective on gene duplication and divergence in livebearers.BMC research notes · 2009Article
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- The evolution of color vision in nocturnal mammals.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Into the blue: gene duplication and loss underlie color vision adaptations in a deep-sea chimaera, the elephant shark Callorhinchus milii.Genome research · 2009Article
- The molecular basis of color vision in colorful fish: four long wave-sensitive (LWS) opsins in guppies (Poecilia reticulata) are defined by amino acid substitutions at key functional sites.BMC evolutionary biology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To elucidate the molecular mechanisms of red-green color vision in mammals, we have cloned and sequenced the red and green opsin cDNAs of cat (Felis catus), horse (Equus caballus), gray squirrel (Sciurus carolinensis), white-tailed deer (Odocoileus virginianus), and guinea pig (Cavia porcellus). These opsins were expressed in COS1 cells and reconstituted with 11-cis-retinal. The purified visual pigments of the cat, horse, squirrel, deer, and guinea pig have lambdamax values at 553, 545, 532, 531, and 516 nm, respectively, which are precise to within +/-1 nm. We also regenerated the "true" red pigment of goldfish (Carassius auratus), which has a lambdamax value at 559 +/- 4 nm. Multiple linear regression analyses show that S180A, H197Y, Y277F, T285A, and A308S shift the lambdamax values of the red and green pigments in mammals toward blue by 7, 28, 7, 15, and 16 nm, respectively, and the reverse amino acid changes toward red by the same extents. The additive effects of these amino acid changes fully explain the red-green color vision in a wide range of mammalian species, goldfish, American chameleon (Anolis carolinensis), and pigeon (Columba livia).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.