ArticleGenetics1999
Appearance and properties of L-sorbose-utilizing mutants of Candida albicans obtained on a selective plate.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- The Dynamic Fungal Genome: Polyploidy, Aneuploidy and Copy Number Variation in Response to Stress.Annual review of microbiology · 2023Review
- Genome-Wide DNA Changes Acquired byMicroorganisms · 2023Article
- The role of aneuploidy in the emergence of echinocandin resistance in human fungal pathogen Candida albicans.PLoS pathogens · 2021Article
- The Impact of Gene Dosage and Heterozygosity on The Diploid PathobiontJournal of fungi (Basel, Switzerland) · 2019Review
- Rapid and extensive karyotype diversification in haploid clinical Candida auris isolates.Current genetics · 2019Article
- Monitoring Phenotypic Switching in Candida albicans and the Use of Next-Gen Fluorescence Reporters.Current protocols in microbiology · 2019Article
- Article
- Transcriptional Regulation on Aneuploid Chromosomes in Divers Candida albicans Mutants.Scientific reports · 2018Article
- NuA4 histone acetyltransferase activity is required for H4 acetylation on a dosage-compensated monosomic chromosome that confers resistance to fungal toxins.Epigenetics & chromatin · 2017Article
- Article
- Plasticity of Candida albicans Biofilms.Microbiology and molecular biology reviews : MMBR · 2016Review
- Adaptation of Candida albicans to growth on sorbose via monosomy of chromosome 5 accompanied by duplication of another chromosome carrying a gene responsible for sorbose utilization.FEMS yeast research · 2014Article
- Rapid mechanisms for generating genome diversity: whole ploidy shifts, aneuploidy, and loss of heterozygosity.Cold Spring Harbor perspectives in medicine · 2014Review
- Large-Scale Chromosomal Changes and Associated Fitness Consequences in Pathogenic Fungi.Current fungal infection reports · 2014Article
- Chromosome 5 monosomy of Candida albicans controls susceptibility to various toxic agents, including major antifungals.Antimicrobial agents and chemotherapy · 2013Article
- DNA methylation regulates phenotype-dependent transcriptional activity in Candida albicans.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Fig1 facilitates calcium influx and localizes to membranes destined to undergo fusion during mating in Candida albicans.Eukaryotic cell · 2011Article
- The parasexual cycle in Candida albicans provides an alternative pathway to meiosis for the formation of recombinant strains.PLoS biology · 2008Article
- Microsatellite DNA identification and genotyping of Candida albicans from Lebanese clinical isolates.Mycopathologia · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
This is the first report that adaptive mutagenesis can arise by chromosomal nondisjunction, a phenomenon previously associated exclusively with DNA alterations. We previously uncovered a novel regulatory mechanism in Candida albicans in which the assimilation of an alternative sugar, l-sorbose, was determined by copy number of chromosome 5, such that monosomic strains utilized l-sorbose, whereas disomic strains did not. We present evidence that this formation of monosomy of chromosome 5, which is apparently a result of nondisjunction, appeared with increased frequencies after a selective condition was applied, i.e., by adaptive mutagenesis. The rate of formation of l-sorbose-utilizing mutants per viable cell per day ranged from 10(-6) at the initial time of detection to 10(-2) after 4 days of incubation on the selective plate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.