ArticleGenetics1999
Molecular evolution of the Escherichia coli chromosome. V. Recombination patterns among strains of diverse origin.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Biology of host-dependent restriction-modification in prokaryotes.EcoSal Plus · 2025Review
- Article
- Resistance and tolerance to foreign elements by prokaryotic immune systems - curating the genome.Nature reviews. Immunology · 2015Review
- Recombinant transfer in the basic genome of Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The Contribution of Genetic Recombination to CRISPR Array Evolution.Genome biology and evolution · 2015Article
- The other face of restriction: modification-dependent enzymes.Nucleic acids research · 2014Review
- Diverse functions of restriction-modification systems in addition to cellular defense.Microbiology and molecular biology reviews : MMBR · 2013Review
- Population genomics in bacteria: a case study of Staphylococcus aureus.Molecular biology and evolution · 2012Article
- The population genetics of commensal Escherichia coli.Nature reviews. Microbiology · 2010Review
- Population genomics and the bacterial species concept.Methods in molecular biology (Clifton, N.J.) · 2009Review
- Population genomic analysis of strain variation in Leptospirillum group II bacteria involved in acid mine drainage formation.PLoS biology · 2008Article
- Genome dynamics in a natural archaeal population.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Sex and virulence in Escherichia coli: an evolutionary perspective.Molecular microbiology · 2006Article
- Evolution of Staphylococcus aureus by large chromosomal replacements.Journal of bacteriology · 2004Article
- Plasmid R16 ArdA protein preferentially targets restriction activity of the type I restriction-modification system EcoKI.Journal of bacteriology · 2003Article
- Phylogenetic and functional analysis of the bacteriophage P1 single-stranded DNA-binding protein.Journal of virology · 2002Article
- Nucleoside triphosphate-dependent restriction enzymes.Nucleic acids research · 2001Review
- Helicobacter pylori genetic diversity and risk of human disease.The Journal of clinical investigation · 2001Review
- Evolutionary dynamics of full genome content in Escherichia coli.The EMBO journal · 2000Article
- Type I restriction systems: sophisticated molecular machines (a legacy of Bertani and Weigle).Microbiology and molecular biology reviews : MMBR · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Incorporation patterns of donor DNA into recipient chromosomes following transduction or conjugation have been studied in the progeny of a variety of Escherichia coli crosses in which donor and recipient nucleotide sequences differ by 1-3%. Series of contiguous or variously spaced PCR fragments have been amplified from each recombinant chromosome and digested with a commercial restriction endonuclease previously shown to distinguish the respective parents in a given fragment. We conclude that entering donor DNA fragments are frequently abridged (cut and shortened) before incorporation, the cutting being due to restriction systems, and the shortening presumably due to exonuclease activity. Analysis of several backcrosses confirms, and extends to conjugation, the importance of restriction in E. coli recombination in nature. The transmission patterns in conjugation are similar to those of transduction, but (as expected) on a much larger scale. Asymmetric results of reciprocal crosses imply that mismatch frequency is not a major factor. Marked differences among the results of simple crosses according to parental strain combinations are consistent with observations that E. coli strains in nature vary dramatically in their restriction-modification systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.