ArticleBritish journal of pharmacology1999
P2Y2 receptor-mediated inhibition of ion transport in distal lung epithelial cells.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Hypotonic shock modulates Na(+) current via a Cl(-) and Ca(2+)/calmodulin dependent mechanism in alveolar epithelial cells.PloS one · 2013Article
- The touching story of purinergic signaling in epithelial and endothelial cells.Purinergic signalling · 2012Review
- ENaCs and ASICs as therapeutic targets.American journal of physiology. Cell physiology · 2012Review
- Rat parotid gland cell differentiation in three-dimensional culture.Tissue engineering. Part C, Methods · 2010Article
- ENaC, renal sodium excretion and extracellular ATP.Purinergic signalling · 2009Article
- UTP regulation of ion transport in alveolar epithelial cells involves distinct mechanisms.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Cation currents in human airway epithelial cells induced by infection with influenza A virus.The Journal of physiology · 2009Article
- Proinflammatory cytokines tumor necrosis factor-alpha and interferon-gamma alter tight junction structure and function in the rat parotid gland Par-C10 cell line.American journal of physiology. Cell physiology · 2008Article
- Interaction of P2 purinergic receptors with cellular macromolecules.Naunyn-Schmiedeberg's archives of pharmacology · 2008Review
- Expression of intermediate-conductance, Ca2+-activated K+ channel (KCNN4) in H441 human distal airway epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2006Article
- Adenosine-evoked Na+ transport in human airway epithelial cells.British journal of pharmacology · 2006Article
- Ion transport regulated by protease-activated receptor 2 in human airway Calu-3 epithelia.British journal of pharmacology · 2005Article
- UTP-dependent inhibition of Na+ absorption requires activation of PKC in endometrial epithelial cells.The Journal of general physiology · 2002Article
- Oxygen-evoked Na+ transport in rat fetal distal lung epithelial cells.The Journal of physiology · 2001Article
- Differential effects of UTP and ATP on ion transport in porcine tracheal epithelium.British journal of pharmacology · 2000Article
- ATP stimulates Cl- secretion and reduces amiloride-sensitive Na+ absorption in M-1 mouse cortical collecting duct cells.The Journal of physiology · 2000Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
1 Rat foetal distal lung epithelial cells were plated onto permeable supports where they became integrated into epithelial sheets that spontaneously generated short circuit current (ISC). 2 Apical ATP (100 microM) evoked a transient fall in ISC that was followed by a rise to a clear peak which, in turn, was succeeded by a slowly developing decline to a value below control. Apical UTP evoked an essentially identical response. 3 UDP and ADP were ineffective whilst ATP had no effect when added to the basolateral solution. These effects thus appear to be mediated by apical P2Y2 receptors. 4 The rising phase of the responses to ATP/UTP was selectively inhibited by anion transport inhibitors but persisted in the presence of amiloride, which abolished the inhibitory effects of both nucleotides. Thus, apical nucleotides appear to evoke a transient stimulation of anion secretion and sustained inhibition of Na+ absorption. 5 Basolateral isoprenaline (10 microM) elicited a rise in ISC but subsequent addition of apical ATP reversed this effect. Conversely, isoprenaline restored ISC to its basal level following stimulation with ATP. Apical P2Y2 receptors and basolateral beta-adrenoceptors thus allow their respective agonists to exert mutually opposing effects on ISC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.