ArticleThe Journal of clinical investigation1999
Human major group rhinoviruses downmodulate the accessory function of monocytes by inducing IL-10.
Article in The Journal of clinical investigation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 82 citations in OpenAlex.
- Short-term repeated HRV-16 exposure results in an attenuated immune response in vivo in humans.PloS one · 2018Trial
- Immunotherapeutic implications on targeting the cytokines produced in rhinovirus-induced immunoreactions.Frontiers in allergy · 2024Review
- Mechanism of Rhinovirus Immunity and Asthma.Frontiers in immunology · 2021Review
- IgE-mediated regulation of IL-10 and type I IFN enhances rhinovirus-induced Th2 differentiation by primary human monocytes.European journal of immunology · 2020Article
- Betamethasone prevents human rhinovirus- and cigarette smoke- induced loss of respiratory epithelial barrier function.Scientific reports · 2018Article
- HRV16 Impairs Macrophages Cytokine Response to a Secondary Bacterial Trigger.Frontiers in immunology · 2018Article
- How does rhinovirus cause the common cold cough?BMJ open respiratory research · 2016Article
- The role of macrophage IL-10/innate IFN interplay during virus-induced asthma.Reviews in medical virology · 2015Review
- Expression and regulation of Schlafen (SLFN) family members in primary human monocytes, monocyte-derived dendritic cells and T cells.Results in immunology · 2015Article
- Infection with Rhinovirus Facilitates Allergen Penetration Across a Respiratory Epithelial Cell Layer.International archives of allergy and immunology · 2015Article
- Macrophage activation state determines the response to rhinovirus infection in a mouse model of allergic asthma.Respiratory research · 2014Article
- Article
- Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation.The Journal of experimental medicine · 2013Article
- Innate and adaptive immune responses against picornaviruses and their counteractions: An overview.World journal of virology · 2012Review
- Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection.Journal of virology · 2011Article
- Rhinoviruses, allergic inflammation, and asthma.Immunological reviews · 2011Review
- Hepatitis C virus (HCV) evades NKG2D-dependent NK cell responses through NS5A-mediated imbalance of inflammatory cytokines.PLoS pathogens · 2010Article
- Human monocytic cells direct the robust release of CXCL10 by bronchial epithelial cells during rhinovirus infection.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2010Article
- Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology.Clinical microbiology reviews · 2010Review
- A longitudinal study of gene expression in healthy individuals.BMC medical genomics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human rhinoviruses (HRVs) are the predominant cause of the common cold. Although this disease is per se rather harmless, HRV infection is considered to set the stage for more dangerous pathogens in vivo. Here we demonstrate that HRV-14, a member of the major group HRV family, can efficiently inhibit antigen-induced T-cell proliferation and T-cell responses to allogeneic monocytes. HRV-14 triggered a significant downregulation of MHC class II molecules on monocytes. Moreover, supernatants from monocytes cultured in the presence of HRV-14 strongly reduced the allogeneic T-cell stimulatory property of untreated monocytes and monocyte-derived dendritic cells (md-DCs), whereas Epstein Barr virus-transformed B-lymphoblastoid cells were not sensitive. Analysis of the supernatant revealed that HRV-14 induced the production of significant amounts of the immunosuppressive cytokine IL-10. The important T-cell stimulatory cytokine IL-12 or the proinflammatory cytokines IL-1beta or TNF-alpha were not detected or were only minimally detected. Finally, monocytes pretreated with HRV-14 were greatly inhibited in their production of IL-12 upon stimulation with IFN-gamma/LPS. These observations suggest that altered cytokine production in mononuclear phagocytes upon interaction with HRV downmodulates appropriate immune responses during the viral infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.