ArticleThe Journal of clinical investigation1999
Epithelial P2X purinergic receptor channel expression and function.
Article in The Journal of clinical investigation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 104 citations in OpenAlex.
- Allergen-induced activation of epithelial P2YThe Journal of allergy and clinical immunology · 2025Article
- Human P2X4 receptor gating is modulated by a stable cytoplasmic cap and a unique allosteric pocket.Science advances · 2025Article
- P2XScience advances · 2024Article
- High-affinity agonism at the P2XNature communications · 2024Article
- Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural Biology.Frontiers in pharmacology · 2022Review
- From Transcriptomics, Metabolomics to Functional Studies: Extracellular ATP Induces TGF-β-Like Epithelial Mesenchymal Transition in Lung Cancer Cells.Frontiers in oncology · 2022Article
- P2X4 receptor regulation of transient receptor potential melastatin type 6 (TRPM6) Mg2+ channels.Pflugers Archiv : European journal of physiology · 2014Article
- Identification of pannexins in rat nasal mucosa.Allergy & rhinology (Providence, R.I.) · 2013Article
- Physiology of cholangiocytes.Comprehensive Physiology · 2013Review
- Rhinovirus-induced IL-1β release from bronchial epithelial cells is independent of functional P2X7.American journal of respiratory cell and molecular biology · 2012Article
- Role of purinergic P2X receptors in the control of liver homeostasis.Wiley interdisciplinary reviews. Membrane transport and signaling · 2012Article
- Activation and regulation of purinergic P2X receptor channels.Pharmacological reviews · 2011Review
- Interaction and interrelation of P2X7 and P2X4 receptor complexes in mouse lung epithelial cells.Cellular and molecular life sciences : CMLS · 2010Article
- ENaC, renal sodium excretion and extracellular ATP.Purinergic signalling · 2009Article
- Nucleotides downregulate aquaporin 2 via activation of apical P2 receptors.Journal of the American Society of Nephrology : JASN · 2009Article
- Effects of extracellular ATP on bovine lung endothelial and epithelial cell monolayer morphologies, apoptoses, and permeabilities.Clinical and vaccine immunology : CVI · 2009Article
- Extracellular ATP and zinc are co-secreted with insulin and activate multiple P2X purinergic receptor channels expressed by islet beta-cells to potentiate insulin secretion.Purinergic signalling · 2008Article
- Extracellular nucleotides stimulate Cl- currents in biliary epithelia through receptor-mediated IP3 and Ca2+ release.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Mathematical model of nucleotide regulation on airway epithelia. Implications for airway homeostasis.The Journal of biological chemistry · 2008Article
- Modulators of ion transport in nasal polyps: an in situ measurement of short-circuit current.Clinical and experimental otorhinolaryngology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
P2X purinergic receptor (P2XR) channels bind ATP and mediate Ca(2+) influx--2 signals that stimulate secretory Cl(-) transport across epithelia. We tested the hypotheses that P2XR channels are expressed by epithelia and that P2XRs transduce extracellular ATP signals into stimulation of Cl(-) transport across epithelia. Electrophysiological data and mRNA analysis of human and mouse pulmonary epithelia and other epithelial cells indicate that multiple P2XRs are broadly expressed in these tissues and that they are active on both apical and basolateral surfaces. Because P2X-selective agonists bind multiple P2XR subtypes, and because P2X agonists stimulate Cl(-) transport across nasal mucosa of cystic fibrosis (CF) patients as well as across non-CF nasal mucosa, P2XRs may provide novel targets for extracellular nucleotide therapy of CF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.