ArticleThe Journal of experimental medicine1999
Inhibitory receptors alter natural killer cell interactions with target cells yet allow simultaneous killing of susceptible targets.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Improving selection of patients with metastatic colorectal cancer to benefit from cetuximab based on KIR genotypes.Journal for immunotherapy of cancer · 2021Trial
- Combination of KIR2DS4 and FcγRIIa polymorphisms predicts the response to cetuximab in KRAS mutant metastatic colorectal cancer.Scientific reports · 2019Trial
- The Golgi complex governs natural killer cell lytic granule positioning to promote directionality in cytotoxicity.Cell reports · 2025Article
- A collagen-based microwell migration assay to study NK-target cell interactions.Scientific reports · 2019Article
- NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing.The Journal of cell biology · 2016Article
- A single amino acid change in inhibitory killer cell Ig-like receptor results in constitutive receptor self-association and phosphorylation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Dynamics of natural killer cell receptor revealed by quantitative analysis of photoswitchable protein.Biophysical journal · 2013Article
- Controlling natural killer cell responses: integration of signals for activation and inhibition.Annual review of immunology · 2013Review
- Article
- Finding Balance: T cell Regulatory Receptor Expression during Aging.Aging and disease · 2011Article
- Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy.PLoS biology · 2011Article
- Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells.The Journal of cell biology · 2011Article
- Mechanisms and functions for the duration of intercellular contacts made by lymphocytes.Nature reviews. Immunology · 2009Review
- Article
- Article
- NK cells rapidly remove B16F10 tumor cells in a perforin and interferon-gamma independent manner in vivo.Cancer immunology, immunotherapy : CII · 2007Article
- Stable masking by H-2Dd cis ligand limits Ly49A relocalization to the site of NK cell/target cell contact.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Microclusters of inhibitory killer immunoglobulin-like receptor signaling at natural killer cell immunological synapses.The Journal of cell biology · 2006Article
- The CD94/NKG2 family of receptors: from molecules and cells to clinical relevance.Immunologic research · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Inhibitory receptors expressed on natural killer (NK) cells abrogate positive signals upon binding corresponding major histocompatibility complex (MHC) class I molecules on various target cells. By directly micromanipulating the effector-target cell encounter using an optical tweezers system which allowed temporal and spatial control, we demonstrate that Ly49-MHC class I interactions prevent characteristic cellular responses in NK cells upon binding to target cells. Furthermore, using this system, we directly demonstrate that an NK cell already bound to a resistant target cell may simultaneously bind and kill a susceptible target cell. Thus, although Ly49-mediated inhibitory signals can prevent many types of effector responses, they do not globally inhibit cellular function, but rather the inhibitory signal is spatially restricted towards resistant targets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.