ArticleThe Journal of experimental medicine1999
A defect in interleukin 12-induced activation and interferon gamma secretion of peripheral natural killer T cells in nonobese diabetic mice suggests new pathogenic mechanisms for insulin-dependent diabetes mellitus.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 134 citations in OpenAlex.
- Activation and Regulation of B Cell Responses by Invariant Natural Killer T Cells.Frontiers in immunology · 2018Review
- Different subsets of natural killer T cells may vary in their roles in health and disease.Immunology · 2014Review
- NKT Cell Subsets Can Exert Opposing Effects in Autoimmunity, Tumor Surveillance and Inflammation.Current immunology reviews · 2012Article
- Helminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-β.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Critical role for invariant chain in CD1d-mediated selection and maturation of Vα14-invariant NKT cells.Immunology letters · 2011Article
- Article
- Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease.Seminars in immunopathology · 2011Review
- Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette.Diabetes · 2010Article
- Intracellular bacterial infection and invariant NKT cells.Yonsei medical journal · 2009Review
- Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKT2 cells in nonobese diabetic mice.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Induction of active tolerance and involvement of CD1d-restricted natural killer T cells in anti-CD3 F(ab')2 treatment-reversed new-onset diabetes in nonobese diabetic mice.The American journal of pathology · 2008Article
- Human chorionic gonadotropin is an immune modulator and can prevent autoimmune diabetes in NOD mice.Diabetologia · 2007Article
- Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The natural killer T lymphocyte: a player in the complex regulation of autoimmune diabetes in non-obese diabetic mice.Clinical and experimental immunology · 2006Review
- An integrated view of suppressor T cell subsets in immunoregulation.The Journal of clinical investigation · 2004Review
- Dissecting autoimmune diabetes through genetic manipulation of non-obese diabetic mice.Diabetologia · 2003Review
- Article
- Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences.Immunology · 2003Review
- Surprisingly minor influence of TRAV11 (Valpha14) polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics.Immunogenetics · 2003Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The function of natural killer T (NKT) cells in the immune system has yet to be determined. There is some evidence that their defect is associated with autoimmunity, but it is still unclear how they play a role in regulating the pathogenesis of T cell-mediated autoimmune diseases. It was originally proposed that NKT cells could control autoimmunity by shifting the cytokine profile of autoimmune T cells toward a protective T helper 2 cell (Th2) type. However, it is now clear that the major function of NKT cells in the immune system is not related to their interleukin (IL)-4 secretion. In fact, NKT cells mainly secrete interferon (IFN)-gamma and, activated in the presence of IL-12, acquire a strong inflammatory phenotype and cytotoxic function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.