ReviewBiological psychiatry1999
Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms.
Review in Biological psychiatry, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01011101 (Internal Monitoring of Eye Movement in Schizophrenia), which is not on this map. Cited by 190 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Internal Monitoring of Eye Movement in Schizophrenia
Who cites it
190 citing papers in PubMed, 1 synthesis or guideline pooled it, 560 citations in OpenAlex.
- Aberrant cortical-subcortical-cerebellar connectivity in resting-state fMRI as an imaging marker of schizophrenia and psychosis: a systematic review of data-driven whole-brain functional connectivity analyses.Frontiers in neuroimaging · 2025Pooled it
- Intermittent theta burst stimulation of cerebellar vermis enhances fronto-cerebellar resting state functional connectivity in schizophrenia with predominant negative symptoms: A randomized controlled trial.Schizophrenia research · 2021Trial
- Acute effects of THC on time perception in frequent and infrequent cannabis users.Psychopharmacology · 2013Trial
- Sparse representation of brain aging: extracting covariance patterns from structural MRI.PloS one · 2012Trial
- Structural magnetic resonance imaging predictors of responsiveness to cognitive behaviour therapy in psychosis.Schizophrenia research · 2009Trial
- Dorsolateral prefrontal cortex activity predicts responsiveness to cognitive-behavioral therapy in schizophrenia.Biological psychiatry · 2009Trial
- [Schizophrenia as a disconnection syndrome. Studies with functional magnetic resonance imaging and structural equation modeling].Der Radiologe · 2005Trial
- Decreased variability of small-world propensity during non-response tasks in schizophrenia.Neuroimage. Reports · 2026Article
- Schizophrenia and disordered sensorimotor control: challenges, mechanisms and opportunities.Brain : a journal of neurology · 2026Review
- Disorganized Inhibitory Dynamics in Hippocampal area CA1 of 22q11.2 Deletion Mutant Mice.bioRxiv : the preprint server for biology · 2026Article
- Frontal-striatal-thalamic circuit dysfunction and inferential processing between internal representations and external events across the psychosis spectrum.Frontiers in psychiatry · 2026Review
- Sex-related differences in the cortico-thalamo-cerebellar circuit in patients with schizophrenia.Frontiers in psychiatry · 2026Article
- Progress and ongoing conceptual challenges "on the way to integrative human neuroscience"-ten years after.Frontiers in integrative neuroscience · 2026Article
- Cerebellar structure and function abnormalities in 16p11.2 microduplication mice.Brain communications · 2026Article
- Thalamocortical Structural Covariation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study.Biological psychiatry · 2025Article
- Review
- Transcriptional Regulators in the Cerebellum in Chronic Schizophrenia: Novel Possible Targets for Pharmacological Interventions.International journal of molecular sciences · 2025Article
- Diagnostic value of regional homogeneity and fractional amplitude of low-frequency fluctuations in the classification of schizophrenia and bipolar disorders.European archives of psychiatry and clinical neuroscience · 2025Article
- A Developmental Perspective on Early and Current Motor Abnormalities and Psychotic-Like Symptoms.Schizophrenia bulletin · 2025Article
- Guideline for pharmacological treatment of schizophrenia 2022.Neuropsychopharmacology reports · 2025Article
130 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
All research on schizophrenia depends on selecting the correct phenotype to define the sample to be studied. Definition of the phenotype is complicated by the fact that there are no objective markers for the disorder. Further, the symptoms are diverse, leading some to propose that the disorder is heterogeneous and not a single disorder or syndrome. This article explores an alternative possibility. It proposes that schizophrenia may be a single disorder linked by a common pathophysiology (a neurodevelopmental mechanism), which leads to a misconnection syndrome of neural circuitry. Evidence for disruption in a specific circuit is explored: the cortical-thalamic-cerebellar-cortical circuit (CCTCC). It is suggested that a disruption in this circuit leads to an impairment in synchrony, or the smooth coordination of mental processes. When synchrony is impaired, the patient suffers from a cognitive dysmetria, and the impairment in this basic cognitive process defines the phenotype of schizophrenia and produces its diversity of symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.