ReviewBiological psychiatry1999
Duration of untreated psychosis in first-episode schizophrenia: marker or determinant of course?
Review in Biological psychiatry, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 72 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 3 syntheses or guidelines pooled it, 374 citations in OpenAlex.
- "Short" Versus "Long" Duration of Untreated Psychosis in People with First-Episode Psychosis: A Systematic Review and Meta-Analysis of Baseline Status and Follow-Up Outcomes.Schizophrenia bulletin · 2025Pooled it
- Early intervention in psychosis services: A systematic review and narrative synthesis of barriers and facilitators to seeking access.European psychiatry : the journal of the Association of European Psychiatrists · 2023Pooled it
- Predictive Factors of Treatment Resistance in First Episode of Psychosis: A Systematic Review.Frontiers in psychiatry · 2019Pooled it
- Early psychosis research at Orygen, The National Centre of Excellence in Youth Mental Health.Social psychiatry and psychiatric epidemiology · 2016Trial
- Trial
- Reducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study.BMC psychiatry · 2014Trial
- Lack of an inverse relationship between duration of untreated psychosis and cognitive function in first episode schizophrenia.Schizophrenia research · 2009Trial
- Recalibrating the Quantitative Relationship Between Duration of Untreated Psychosis and Outcome for Health Service Models.Early intervention in psychiatry · 2026Article
- Schizophrenia detection via lobe-wise and overall EEG features using VMD and bayesian-optimized machine learning models.Frontiers in neuroscience · 2026Article
- Duration of untreated psychosis and diagnostic delay in homeless patients with schizophrenia- a Copenhagen based clinical study.Social psychiatry and psychiatric epidemiology · 2025Article
- DCM-ML: An Electroencephalography-based Classifier for Early Diagnosis of Schizophrenia Based on Dynamic Connectivity Matrices and Machine Learning Algorithms.Basic and clinical neuroscience · 2025Article
- Sex differences in outcomes of first episode psychosis: results from an early intervention service.Frontiers in behavioral neuroscience · 2025Article
- Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?European child & adolescent psychiatry · 2024Article
- Article
- Receiving or not deemed necessary healthcare services.BMC public health · 2023Article
- Fractal dimension analysis of resting state functional networks in schizophrenia from EEG signals.Frontiers in human neuroscience · 2023Article
- The mood disorder spectrum vs. schizophrenia decision tree: EDIPHAS research into the childhood and adolescence of 205 patients.BMC psychiatry · 2022Article
- Reducing the Duration of Untreated Psychosis (DUP) in a US Community: A Quasi-Experimental Trial.Schizophrenia bulletin open · 2022Article
- Granular analysis of pathways to care and durations of untreated psychosis: A marginal delay model.PloS one · 2022Article
- Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study.Schizophrenia bulletin · 2021Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The natural history of schizophrenia is often chronic and debilitating, an enduring fact that draws attention to the first episode and early course of the disorder when neurobiological deficits apparently form. Many recent studies have focused on the duration of untreated psychosis (DUP) in first-episode patients for reasons that are reviewed here. DUP is often months or years in length, making it a major public mental health problem. Reducing DUP through early detection may be possible from a service systems perspective. This may be very important because earlier treatment not only reduces acute psychotic symptoms, but may also improve long-term prognosis by attenuating the deficit processes active at this time; processes that are either signaled by or a product of DUP. Finally, DUP appears to influence sampling in first-episode research in that longer DUP is associated with higher recruitment refusal rates to studies. For all of these reasons, DUP should be added to the battery of descriptive variables routinely collected on all patients with schizophrenia, whether for treatment or research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.