ArticleBiological psychiatry1999
Childhood-onset schizophrenia: progressive brain changes during adolescence.
Article in Biological psychiatry, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 227 citations in OpenAlex.
- Brain structure and function in adult survivors of developmental trauma with psychosis: A systematic review.Psychological medicine · 2025Pooled it
- Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia.Brain stimulation · 2011Trial
- An uncommon neuroradiological finding of hippocampal malrotation in childhood onset schizophrenia and 22q11.2 Deletion Syndrome: a case report and a brief review of the literature.European child & adolescent psychiatry · 2025Review
- MRI Volumetric Analysis of the Hypothalamus and Limbic System across the Pediatric Age Span.Children (Basel, Switzerland) · 2023Article
- Morphological Abnormalities in Early-Onset Schizophrenia Revealed by Structural Magnetic Resonance Imaging.Biology · 2023Article
- Thalamic Shape Abnormalities Differentially Relate to Cognitive Performance in Early-Onset and Adult-Onset Schizophrenia.Frontiers in psychiatry · 2022Article
- Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells.International journal of molecular sciences · 2018Review
- Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment.Molecular psychiatry · 2018Article
- The complement system: a gateway to gene-environment interactions in schizophrenia pathogenesis.Molecular psychiatry · 2017Review
- A prenatal interruption of DISC1 function in the brain exhibits a lasting impact on adult behaviors, brain metabolism, and interneuron development.Oncotarget · 2017Article
- Influence of early trauma on features of schizophrenia.Early intervention in psychiatry · 2017Article
- Lack of Gender-Related Differences in Childhood-Onset Schizophrenia.Journal of the American Academy of Child and Adolescent Psychiatry · 2016Article
- Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings.Schizophrenia research · 2016Review
- Structural Brain Abnormalities in Youth With Psychosis Spectrum Symptoms.JAMA psychiatry · 2016Article
- Age at First Episode Modulates Diagnosis-Related Structural Brain Abnormalities in Psychosis.Schizophrenia bulletin · 2016Article
- Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure.PloS one · 2016Article
- Disrupted sensorimotor and social-cognitive networks underlie symptoms in childhood-onset schizophrenia.Brain : a journal of neurology · 2016Article
- Preferential detachment during human brain development: age- and sex-specific structural connectivity in diffusion tensor imaging (DTI) data.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Brain network informed subject community detection in early-onset schizophrenia.Scientific reports · 2014Article
- Adolescent brain maturation and cortical folding: evidence for reductions in gyrification.PloS one · 2014Article
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14 authors at 1 institution in 1 country.
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Abstract
backgroundPrevious NIMH childhood onset schizophrenia (COS) anatomic brain MRI studies found progression of ventricular volume and other structural brain anomalies at 2-year follow up across mean ages 14 to 16 years. However, studies in adult patients generally do not show progression of ventricular volume or correlation of ventricular volume with duration of illness. To address issues of progression of brain anomalies in schizophrenia, this report extends previous studies to include a third longitudinal scan, uses a larger sample size, and includes measures of the amygdala and hippocampus.
methodsVolumes of the total cerebrum, lateral ventricles, hippocampus, and amygdala were quantified on 208 brain magnetic resonance imaging scans from 42 adolescents with COS (23 with one or more repeat scan) and 74 age- and gender-matched controls (36 with one or more repeat scan). A statistical technique permitting combined use of cross-sectional and longitudinal data was used to assess age-related changes, linearity, and diagnostic group differences.
resultsDifferential nonlinear progression of brain anomalies was seen during adolescence with the total cerebrum and hippocampus decreasing and lateral ventricles increasing in the COS group. The developmental curves for these structures reached an asymptote by early adulthood for the COS group and did not significantly change with age in the control group.
conclusionsThese findings reconcile less striking progression of anatomic brain images usually seen for adult schizophrenia and complement other data consistent with time-limited, diagnostic-specific decreases in brain tissue. Adolescence appears to be a unique period of differential brain development in schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.