ArticleThe Journal of cell biology1999
Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 75 citations in OpenAlex.
- Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus.Cells · 2021Review
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- Extraribosomal Functions of Cytosolic Ribosomal Proteins in Plants.Frontiers in plant science · 2021Review
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- Hallmarks of ribosomopathies.Nucleic acids research · 2020Review
- Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells.Nature communications · 2019Article
- Biological Function of Ribosomal Protein L10 on Cell Behavior in Human Epithelial Ovarian Cancer.Journal of Cancer · 2018Article
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- NIK1-mediated translation suppression functions as a plant antiviral immunity mechanism.Nature · 2015Article
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- Inactivation of X-linked tumor suppressor genes in human cancer.Future oncology (London, England) · 2012Review
- Arabidopsis L10 ribosomal proteins in UV-B responses.Plant signaling & behavior · 2010Article
- Plant L10 ribosomal proteins have different roles during development and translation under ultraviolet-B stress.Plant physiology · 2010Article
- Contributions of Zur-controlled ribosomal proteins to growth under zinc starvation conditions.Journal of bacteriology · 2009Article
- How common are extraribosomal functions of ribosomal proteins?Molecular cell · 2009Review
- Regulated nuclear trafficking of rpL10A mediated by NIK1 represents a defense strategy of plant cells against virus.PLoS pathogens · 2008Article
- Histone acetylation and chromatin remodeling are required for UV-B-dependent transcriptional activation of regulated genes in maize.The Plant cell · 2008Article
- Reduction of QM protein expression correlates with tumor grade in prostatic adenocarcinoma.Prostate cancer and prostatic diseases · 2006Article
- T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice.The Journal of experimental medicine · 2002Article
- Dysregulation of cellular calcium homeostasis in Alzheimer's disease: bad genes and bad habits.Journal of molecular neuroscience : MN · 2001Review
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Presenilin 1 (PS1) is the causative gene for an autosomal dominant familial Alzheimer's disease (AD) mapped to chromosome 14. Here we show that QM/Jun-interacting factor (Jif)-1, a negative regulator of c-Jun, is a candidate to mediate the function of PS1 in the cell. We screened for proteins that bind to PS1 from a human embryonic brain cDNA library using the two-hybrid method and isolated one clone encoding the QM/Jif-1 gene. The binding of QM/Jif-1 to full-length PS1 was confirmed in vitro by pull-down assay, and in vivo by immunoprecipitation assays with human samples, including AD brains. Immunoelectronmicroscopic analysis showed that QM/Jif-1 and PS1 are colocalized at the endoplasmic reticulum, and the nuclear matrix in human brain neurons. Chloramphenicol acetyltransferase assays in F9 cells showed that PS1 suppresses transactivation by c-Jun/c-Jun but not by c-Jun/c-Fos heterodimers, consistent with the reported function of QM/Jif-1. By monitoring fluorescent recombinant protein and by gel mobility shift assays, PS1 was shown to accelerate the translocation of QM from the cytoplasm to the nucleus and to thereby suppress the binding of c-Jun homodimer to 12-O-tetradecanoylphorbol-13- acetate (TPA)-responsive element (TRE). PS1 suppressed c-jun-associated apoptosis by retinoic acid in F9 embryonic carcinoma cells, whereas this suppression of apoptosis is attenuated by mutation in PS1. Collectively, the novel function of PS1 via QM/Jif-1 influences c-jun-mediated transcription and apoptosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.