ArticleGenome research1999
Effects of worldwide population subdivision on ALDH2 linkage disequilibrium.
Article in Genome research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- An investigation into the potential effects of infrapopulation structure and other sources of sampling error, on population genetic studies of the transmission of Schistosoma japonicum (Trematoda: Digenea).Parasites & vectors · 2016Article
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- Genome-wide association studies of alcohol intake--a promising cocktail?The American journal of clinical nutrition · 2011Article
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- ADH1B*3 and response to alcohol in African-Americans.Alcoholism, clinical and experimental research · 2010Article
- Association of substance use disorders with childhood trauma but not African genetic heritage in an African American cohort.The American journal of psychiatry · 2009Article
- Association of slow N-acetyltransferase 2 profile and anti-TB drug-induced hepatotoxicity in patients from Southern Brazil.European journal of clinical pharmacology · 2008Article
- Ascertainment bias and the pattern of nucleotide diversity at the human ALDH2 locus in a Japanese population.Journal of molecular evolution · 2007Article
- Simultaneous detection of linkage disequilibrium and genetic differentiation of subdivided populations.Genetics · 2004Article
- Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism.Molecular psychiatry · 2004Review
- Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes.BMC genetics · 2004Article
- Haplotype structure and linkage disequilibrium in chemokine and chemokine receptor genes.Human genomics · 2004Article
- Characterisation of SNP haplotype structure in chemokine and chemokine receptor genes using CEPH pedigrees and statistical estimation.Human genomics · 2004Article
- A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity.American journal of human genetics · 2002Article
- Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus.American journal of human genetics · 2002Article
- Association of a 5-HT(5A) receptor polymorphism, Pro15Ser, to schizophrenia.Molecular psychiatry · 2001Article
- Article
- Short tandem-repeat polymorphism/alu haplotype variation at the PLAT locus: implications for modern human origins.American journal of human genetics · 2000Article
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3 authors.
Funding
Abstract
The effect of human population subdivision on linkage disequilibrium has previously been studied for unlinked genes. However, no study has focused on closely linked polymorphisms or formally partitioned linkage disequilibrium within and among worldwide populations. With an emphasis on population subdivision, the goal of this paper is to investigate the causes of linkage disequilibrium in ALDH2, the gene that encodes aldehyde dehydrogenase 2. Haplotypes for 756 people from 17 populations across five continents were estimated by maximum-likelihood from genotypes at six closely linked ALDH2 nucleotide substitutions. Linkage disequilibrium was partitioned into three components: within populations, among populations within continents, and among continents. It was found that population subdivision among continents had a larger and more disparate effect on linkage disequilibrium than subdivision among local populations. Further, linkage disequilibrium did not increase with population divergence as predicted by a simple model. Rather, the patterns of linkage disequilibrium were complicated because of the interplay of a near absence of recombination, the linkage disequilibrium that existed prior to the divergence of modern humans, subsequent mutation, population subdivision, random genetic drift, and perhaps natural selection. These results suggest that simple models may not well predict patterns of linkage disequilibrium in human populations.
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