ArticleGenome research1999
Comparative analysis of noncoding regions of 77 orthologous mouse and human gene pairs.
Article in Genome research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed.
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- The EMBL-EBI search and sequence analysis tools APIs in 2019.Nucleic acids research · 2019Article
- Analysis of the Functional Relevance of Epigenetic Chromatin Marks in the First Intron Associated with Specific Gene Expression Patterns.Genome biology and evolution · 2019Article
- Polymorphism of the 3'-UTR of the dopamine transporter gene (DAT) in New World monkeys.Primates; journal of primatology · 2017Article
- Introns: The Functional Benefits of Introns in Genomes.Genomics & informatics · 2015Review
- Conservation in first introns is positively associated with the number of exons within genes and the presence of regulatory epigenetic signals.BMC genomics · 2014Article
- A genome-wide analysis of genetic diversity in Trypanosoma cruzi intergenic regions.PLoS neglected tropical diseases · 2014Article
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- Mammalian NUMT insertion is non-random.Nucleic acids research · 2012Article
- Evolutionary genomics of Colias Phosphoglucose Isomerase (PGI) introns.Journal of molecular evolution · 2012Article
- Fitness effects of derived deleterious mutations in four closely related wild tomato species with spatial structure.Heredity · 2011Article
- Species-specific strategies underlying conserved functions of metabolic transcription factors.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications.International journal of molecular epidemiology and genetics · 2011Article
- A genome alignment algorithm based on compression.BMC bioinformatics · 2010Article
- A comparative approach shows differences in patterns of numt insertion during hominoid evolution.Journal of molecular evolution · 2009Article
- Evolution of transcription factor binding sites in mammalian gene regulatory regions: handling counterintuitive results.Journal of molecular evolution · 2009Article
- Fast evolution of core promoters in primate genomes.Molecular biology and evolution · 2008Article
- Comparative analysis of sequence features involved in the recognition of tandem splice sites.BMC genomics · 2008Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
A data set of 77 genomic mouse/human gene pairs has been compiled from the EMBL nucleotide database, and their corresponding features determined. This set was used to analyze the degree of conservation of noncoding sequences between mouse and human. A new alignment algorithm was developed to cope with the fact that large parts of noncoding sequences are not alignable in a meaningful way because of genetic drift. This new algorithm, DNA Block Aligner (DBA), finds colinear-conserved blocks that are flanked by nonconserved sequences of varying lengths. The noncoding regions of the data set were aligned with DBA. The proportion of the noncoding regions covered by blocks >60% identical was 36% for upstream regions, 50% for 5' UTRs, 23% for introns, and 56% for 3' UTRs. These blocks of high identity were more or less evenly distributed across the length of the features, except for upstream regions in which the first 100 bp upstream of the transcription start site was covered in up to 70% of the gene pairs. This data set complements earlier sets on the basis of cDNA sequences and will be useful for further comparative studies. [This paper contains supplementary data that can be found at http://www.genome.org [corrected]].
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