ArticleBritish journal of cancer1999
Fish oil supplementation enhanced CPT-11 (irinotecan) efficacy against MCF7 breast carcinoma xenografts and ameliorated intestinal side-effects.
Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 77 citations in OpenAlex.
- Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial.British journal of cancer · 2009Trial
- Nutrition intervention using an eicosapentaenoic acid (EPA)-containing supplement in patients with advanced colorectal cancer. Effects on nutritional and inflammatory status: a phase II trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2007Trial
- Managing Irinotecan-Induced Diarrhea: A Comprehensive Review of Therapeutic Interventions in Cancer Treatment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Camptothesome elicits immunogenic cell death to boost colorectal cancer immune checkpoint blockade.Journal of controlled release : official journal of the Controlled Release Society · 2022Article
- Epigenetic Reprogramming Mediated by Maternal Diet Rich in Omega-3 Fatty Acids Protects From Breast Cancer Development in F1 Offspring.Frontiers in cell and developmental biology · 2021Article
- ω-3 Long Chain Polyunsaturated Fatty Acids as Sensitizing Agents and Multidrug Resistance Revertants in Cancer Therapy.International journal of molecular sciences · 2017Review
- Chemotherapy-induced gastrointestinal toxicity is associated with changes in serum and urine metabolome and fecal microbiota in male Sprague-Dawley rats.Cancer chemotherapy and pharmacology · 2017Article
- HuangQin Decoction Attenuates CPT-11-Induced Gastrointestinal Toxicity by Regulating Bile Acids Metabolism Homeostasis.Frontiers in pharmacology · 2017Article
- Diet composition as a source of variation in experimental animal models of cancer cachexia.Journal of cachexia, sarcopenia and muscle · 2016Review
- Downregulation of ABCE1 via siRNA affects the sensitivity of A549 cells against chemotherapeutic agents.Medical oncology (Northwood, London, England) · 2015Article
- Therapeutic targeting of CPT-11 induced diarrhea: a case for prophylaxis.Current drug targets · 2013Review
- Article
- Effects of caloric intake on intestinal mucosal morphology and immune cells in rats treated with 5-Fluorouracil.Journal of clinical biochemistry and nutrition · 2009Article
- Cancer stem/progenitor cell active compound 8-quinolinol in combination with paclitaxel achieves an improved cure of breast cancer in the mouse model.Breast cancer research and treatment · 2009Article
- Lectin microarrays identify cell-specific and functionally significant cell surface glycan markers.Glycobiology · 2008Article
- NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells.Breast cancer research and treatment · 2008Article
- Optical imaging of tumor cells in hollow fibers: evaluation of the antitumor activities of anticancer drugs and target validation.Neoplasia (New York, N.Y.) · 2007Article
- Protective role of fish oil (Maxepa) on early events of rat mammary carcinogenesis by modulation of DNA-protein crosslinks, cell proliferation and p53 expression.Cancer cell international · 2007Article
- Dietary omega-3 fatty acids and ionizing irradiation on human breast cancer xenograft growth and angiogenesis.Cancer cell international · 2005Article
- Role of lipid peroxidation and antioxidant enzymes in omega 3 fatty acids induced suppression of breast cancer xenograft growth in mice.Cancer cell international · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The cancer chemotherapeutic efficacy of the topoisomerase I inhibitor, CPT-11 (irinotecan) is often limited by the induction of severe delayed diarrhoea. In animal studies, CPT-11 use is associated with histopathological damage to the mucosa of the small and large intestines. Results from the present study demonstrate that 60 mg CPT-11 per kg body weight (i.v. q4d x 6) halted the growth, but did not cause significant regression, of MCF7 human breast carcinoma xenografts in mice fed a diet containing 7% corn oil. However, when the diet of the MCF7-bearing mice was supplemented with 3% or 6% fish oil, the same CPT-11 treatment caused significant regression of the MCF7 xenograft. Histomorphometric analyses of intestinal mucosa of mice treated with CPT-11 and fed the diet containing 7% com oil indicated that treatment with CPT-11 induced structural changes in the intestinal mucosa which persisted at least 5 days after the last dose of CPT-11. The intestinal mucosal architecture of mice that were treated with CPT-11 and fed the diets containing fish oil was largely unchanged from the architecture of the group of mice which did not receive CPT-11. These findings indicate that fish oil supplements may be a useful adjunct to CPT-11 treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.