ArticleGene therapy1999
Targeting an adenoviral gene vector to cytokine-activated vascular endothelium via E-selectin.
Article in Gene therapy, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 78 citations in OpenAlex.
- Targeting therapeutics to endothelium: are we there yet?Drug delivery and translational research · 2018Review
- Targeted endothelial nanomedicine for common acute pathological conditions.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- Endothelial nanomedicine for the treatment of pulmonary disease.Expert opinion on drug delivery · 2015Review
- Vascular targeting of nanocarriers: perplexing aspects of the seemingly straightforward paradigm.ACS nano · 2014Review
- Targeted interception of signaling reactive oxygen species in the vascular endothelium.Therapeutic delivery · 2012Review
- Article
- Targeted modulation of reactive oxygen species in the vascular endothelium.Journal of controlled release : official journal of the Controlled Release Society · 2011Article
- Targeting antioxidant and antithrombotic biotherapeutics to endothelium.Seminars in thrombosis and hemostasis · 2010Review
- Targeted delivery of therapeutics to endothelium.Cell and tissue research · 2009Review
- Vascular targeting: recent advances and therapeutic perspectives.Trends in cardiovascular medicine · 2006Review
- Cytokine-mediated downregulation of coxsackievirus-adenovirus receptor in endothelial cells.Journal of virology · 2004Article
- Targeting gene therapy vectors to the vascular endothelium.Current atherosclerosis reports · 2003Review
- Cell physiology as a variable in gene transfer to endothelium.Current atherosclerosis reports · 2003Review
- Immunopathogenesis of vasculitis.Current rheumatology reports · 2002Review
- Viral vectors for vascular gene therapy.Experimental and clinical cardiology · 2002Article
- Recombinant human adenovirus: targeting to the human transferrin receptor improves gene transfer to brain microcapillary endothelium.Journal of virology · 2000Article
- The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series).Pulmonary circulationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
We have aimed at selective gene delivery to vascular endothelial cells (EC) at sites of inflammation, by targeting E-selectin, a surface adhesion molecule that is only expressed by activated EC. An anti-E-selectin mAb, 1.2B6, was complexed with the adenovirus vector AdZ.FLAG (expressing the FLAG peptide) by conjugating it to an anti-FLAG mAb. Gene transduction of cultured EC was increased 20-fold compared with AdZ.FLAG complexed with a control bsAb providing EC were activated by cytokines. The anti-E-selectin-complexed vector transduced 29 +/- 9% of intimal EC in segments of pig aorta cultured with cytokines ex vivo, compared with less than 0.1% transduced with the control construct (P < 0.05). This strategy could be developed to target endothelium in inflammation with genes capable of modifying the inflammatory response.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.