ReviewJournal of neurobiology1999
Molecular analysis of developmental plasticity in neocortex.
Review in Journal of neurobiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses.eLife · 2022Article
- Article
- Rapid Changes in Cortical and Subcortical Brain Regions after Early Bilateral Enucleation in the Mouse.PloS one · 2015Article
- Neonatal infection modulates behavioral flexibility and hippocampal activation on a Morris Water Maze task.Physiology & behavior · 2014Article
- Acute synthesis of CPEB is required for plasticity of visual avoidance behavior in Xenopus.Cell reports · 2014Article
- Bilateral enucleation alters gene expression and intraneocortical connections in the mouse.Neural development · 2012Article
- The synaptic proteome during development and plasticity of the mouse visual cortex.Molecular & cellular proteomics : MCP · 2011Article
- The regulation of dendritic arbor development and plasticity by glutamatergic synaptic input: a review of the synaptotrophic hypothesis.The Journal of physiology · 2008Review
- Polo-like kinases in the nervous system.Oncogene · 2005Review
- CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors.Neuron · 2004Article
- Identification of calcium- and nitric oxide-regulated genes by differential analysis of library expression (DAzLE).Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- The neurobiology of opiate tolerance, dependence and sensitization: mechanisms of NMDA receptor-dependent synaptic plasticity.Neurotoxicity research · 2002Article
- Extended plasticity of visual cortex in dark-reared animals may result from prolonged expression of cpg15-like genes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Experience-dependent plasticity of mouse visual cortex in the absence of the neuronal activity-dependent marker egr1/zif268.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Developmental regulation of CPG15 expression in Xenopus.The Journal of comparative neurology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Gene expression studies indicate that during activity-dependent developmental plasticity, N-methyl-D-aspartate receptor activation causes a Ca(2+)-dependent increase in expression of transcription factors and their downstream targets. The products of these plasticity genes then operate collectively to bring about the structural and functional changes that underlie ocular dominance plasticity in visual cortex. Identifying and characterizing plasticity genes provides a tool for molecular dissection of the mechanisms involved. Members of second-messenger pathways identified in adult plasticity paradigms and elements of the transmission machinery are the first candidate plasticity genes tested for their role in activity-dependent developmental plasticity. Knockout mice with deletions of such genes have allowed analyzing their function in the context of different systems and in different paradigms. Studies of mutant mice reveal that activity-dependent plasticity is not necessarily a unified phenomenon. The relative importance of a gene can vary with the context of its expression during different forms of plasticity. Forward genetic screens provide additional new candidates for testing, some with well-defined cellular functions that provide insight into possible plasticity mechanisms.
Indexed as
Identifiers
10504201PMC3062904What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.