ArticleThe Journal of experimental medicine1999
Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Valpha14 natural killer T cells.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 155 citations in OpenAlex.
- Characterization of antibodies induced by immunization of mice with isoglobotrihexosylceramide (iGb3).Biochemistry and biophysics reports · 2024Article
- Lipid-Reactive T Cells in Immunological Disorders of the Lung.Frontiers in immunology · 2018Review
- Carbohydrates as T-cell antigens with implications in health and disease.Glycobiology · 2016Review
- Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation.Mucosal immunology · 2016Article
- A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy.Nature chemical biology · 2014Article
- Activation of invariant natural killer T cells in regional lymph nodes as new antigen-specific immunotherapy via induction of interleukin-21 and interferon-γ.Clinical and experimental immunology · 2014Article
- Effects of mycobacteria major secretion protein, Ag85B, on allergic inflammation in the lung.PloS one · 2014Article
- Lymphocyte-based model systems for allergy research: a historic overview.International archives of allergy and immunology · 2014Review
- The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity.Nature immunology · 2011Article
- The split personality of NKT cells in malignancy, autoimmune and allergic disorders.Immunotherapy · 2011Review
- Article
- Natural killer T cells are dispensable in the development of allergen-induced airway hyperresponsiveness, inflammation and remodelling in a mouse model of chronic asthma.Clinical and experimental immunology · 2010Article
- A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Induction of active tolerance and involvement of CD1d-restricted natural killer T cells in anti-CD3 F(ab')2 treatment-reversed new-onset diabetes in nonobese diabetic mice.The American journal of pathology · 2008Article
- Recent advances in the role of NKT cells in allergic diseases and asthma.Current allergy and asthma reports · 2008Review
- Glycolipid-activated NKT cells support the induction of persistent plasma cell responses and antibody titers.European journal of immunology · 2008Article
- Requirement for CD1d expression by B cells to stimulate NKT cell-enhanced antibody production.Blood · 2008Article
- OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice.The Journal of clinical investigation · 2007Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Murine Valpha14 natural killer T (NKT) cells are thought to play a crucial role in various immune responses, including infectious, allergic, and autoimmune diseases. Because Valpha14 NKT cells produce large amounts of both interleukin (IL)-4 and interferon (IFN)-gamma upon in vivo stimulation with a specific ligand, alpha-galactosylceramide (alpha-GalCer), or after treatment with anti-CD3 antibody, a regulatory role on helper T (Th) cell differentiation has been proposed for these cells. However, the identity of the cytokine produced by Valpha14 NKT cells that play a dominant role on the Th cell differentiation still remains controversial. Here, we demonstrate by using Valpha14 NKT-deficient mice that Valpha14 NKT cells are dispensable for the induction of antigen-specific immunoglobulin (Ig)E responses induced by ovalbumin immunization or Nippostrongylus brasiliensis infection. However, upon in vivo activation with alpha-GalCer, Valpha14 NKT cells are found to suppress antigen-specific IgE production. The suppression appeared to be IgE specific, and was not detected in either Valpha14 NKT- or IFN-gamma-deficient mice. Consistent with these results, we also found that ligand-activated Valpha14 NKT cells inhibited Th2 cell differentiation in an in vitro induction culture system. Thus, it is likely that activated Valpha14 NKT cells exert a potent inhibitory effect on Th2 cell differentiation and subsequent IgE production by producing a large amount of IFN-gamma. In marked contrast, our studies have revealed that IL-4 produced by Valpha14 NKT cells has only a minor effect on Th2 cell differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.