ArticleThe Journal of experimental medicine1999
Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- B cells modulate lung antiviral inflammatory responses via the neurotransmitter acetylcholine.Nature immunology · 2025Article
- B Quiet: Autoantigen-Specific Strategies to Silence Raucous B Lymphocytes and Halt Cross-Talk with T Cells in Type 1 Diabetes.Biomedicines · 2021Review
- Structural basis of Focal Adhesion Kinase activation on lipid membranes.The EMBO journal · 2020Article
- BCR-Induced CaCell reports · 2020Article
- Calcium Signaling: From Normal B Cell Development to Tolerance Breakdown and Autoimmunity.Clinical reviews in allergy & immunology · 2017Review
- B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes.Journal of clinical medicine · 2016Article
- Notch1 is an important mediator for enhancing of B-cell activation and antibody secretion by Notch ligand.Immunology · 2014Article
- Article
- B lymphocytes: development, tolerance, and their role in autoimmunity-focus on systemic lupus erythematosus.Autoimmune diseases · 2013Review
- Autoantigen-specific B-cell depletion overcomes failed immune tolerance in type 1 diabetes.Diabetes · 2012Article
- Developmentally regulated expression of MEF2C limits the response to BCR engagement in transitional B cells.European journal of immunology · 2012Article
- Differential STIM1 expression in T and B cell subsets suggests a role in determining antigen receptor signal amplitude.Molecular immunology · 2011Article
- B cell receptor editing in tolerance and autoimmunity.Annals of the New York Academy of Sciences · 2011Review
- Article
- Reduced receptor editing in lupus-prone MRL/lpr mice.The Journal of experimental medicine · 2007Article
- Defective gene expression, S phase progression, and maturation during hematopoiesis in E2F1/E2F2 mutant mice.Molecular and cellular biology · 2003Article
- Positive and negative selection during B lymphocyte development.Immunologic research · 2003Review
- Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced.The Journal of experimental medicine · 2002Article
- Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production.The Journal of experimental medicine · 2000Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although it is well established that immature B lymphocytes are exquisitely sensitive to tolerance induction compared with their mature counterparts, the molecular basis for this difference is unknown. We demonstrate that signaling by B cell antigen receptors leads to distinct and mutually exclusive biologic responses in mature and immature B cells: upregulation of CD86, CD69, and MHC class II in mature cells and receptor editing in immature cells. These responses can be induced simply by elevation of intracellular free calcium levels, as occurs after receptor aggregation. Importantly, induction of immature B cell responses requires much smaller increases in intracellular free calcium than does induction of mature B cell responses. These differences in biologic response and sensitivity to intracellular free calcium likely contributes to selective elimination at the immature stage of even those B cells that express low affinity for self-antigens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.