Evidence map›Paper›PMID 10498903›Full record

ArticleOncogene1999

Distinction between AP1 and NF-E2 factor-binding at specific chromatin regions in mammalian cells.

P Daftari, N R Gavva, C K Shen

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  13. A major role for the TATA box in recruitment of chromatin modifying complexes to a globin gene promoter.Proceedings of the National Academy of Sciences of the United States of America · 2003
    Article
  14. Article
  15. Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain.Proceedings of the National Academy of Sciences of the United States of America · 2002
    Article
  16. Article
  17. Article
  18. Loading of DNA-binding factors to an erythroid enhancer.Molecular and cellular biology · 2000
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

P DaftariSection of Molecular and Cellular Biology, University of California, Davis, California, CA 95616, USA.
N R Gavva
C K Shen
Institute of Molecular Biology, Academia Sinica · TWUniversity of California, Davis · US

Funding

STRUCTURE AND REGULATION OF HUMAN GLOBIN GENE CLUSTERSR01DK029800 · NIDDK · UNIVERSITY OF CALIFORNIA DAVIS · PI SHEN, CHE-KUN J · 1986 to 1998
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NIDDK NIH HHS DK29800
6 · The paper itself

Abstract

Specific nuclear factor-DNA complexes formed within the promoters and enhancers are essential for transcriptional regulation. For eukaryotic systems, however, some DNA motif(s) are capable of binding to a family of related factors, thus making it difficult to identify the factor actually binding on the chromatic DNA in vivo and modulating the local transcription processes. To resolve this matter, we have refined a chromatin immunoprecipitation assay. Using the assay, we could directly link the regulatory functions of two members of the AP1/NF-E2 transcription factor family and their stable binding in vivo within distinct chromatin regions. The study demonstrated the feasibility of a general scheme in the determination of the identity of specific factor(s), among a group of family members, bound at unique sequence(s) in living mammalian cells.

Indexed as

ChromatinDeoxyribonuclease IDNADNA-Binding ProteinsEnhancer Elements, GeneticErythroid-Specific DNA-Binding FactorsGlobinsHumansK562 CellsNF-E2 Transcription FactorNF-E2 Transcription Factor, p45 SubunitPromoter Regions, GeneticProtein BindingProto-Oncogene Proteins c-junTranscription Factor AP-1Transcription FactorsChromatinDeoxyribonuclease IDNADNA-Binding ProteinsErythroid-Specific DNA-Binding FactorsGlobinsNFE2 protein, humanNF-E2 Transcription FactorNF-E2 Transcription Factor, p45 SubunitProto-Oncogene Proteins c-junTranscription Factor AP-1Transcription Factors

Identifiers

PMID10498903
OpenAlexW2082881281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.