ArticleOncogene1999
hpttg is over-expressed in pituitary adenomas and other primary epithelial neoplasias.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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Who cites it
48 citing papers in PubMed, 152 citations in OpenAlex.
- SPTBN1 Mediates the Cytoplasmic Constraint of PTTG1, Impairing Its Oncogenic Activity in Human Seminoma.International journal of molecular sciences · 2023Article
- Article
- Securin overexpression correlates with the activated Rb/E2F1 pathway and histone H3 epigenetic modifications in raw areca nut-induced carcinogenesis in mice.Cancer cell international · 2022Article
- Nuclear Localization of PTTG1 Promotes Migration and Invasion of Seminoma Tumor through Activation of MMP-2.Cancers · 2021Article
- A five-gene signature predicts overall survival of patients with papillary renal cell carcinoma.PloS one · 2019Article
- Expression of cell cycle regulators and biomarkers of proliferation and regrowth in human pituitary adenomas.Pituitary · 2017Article
- Transcriptome Analysis Showed a Differential Signature between Invasive and Non-invasive Corticotrophinomas.Frontiers in endocrinology · 2017Article
- Prognostic implications of securin expression and sub-cellular localization in human breast cancer.Cellular oncology (Dordrecht, Netherlands) · 2016Article
- Animal models of pituitary neoplasia.Molecular and cellular endocrinology · 2016Review
- PTTG1 expression is associated with hyperproliferative disease and poor prognosis in multiple myeloma.Journal of hematology & oncology · 2015Article
- Roles of miR-186 and PTTG1 in colorectal neuroendocrine tumors.International journal of clinical and experimental medicine · 2015Article
- Pituitary tumor-transforming gene 1 is expressed in primary ductal breast carcinoma, lymph node infiltration, and distant metastases.Disease markers · 2013Article
- Expression of PTTG1 and PTEN in endometrial carcinoma: correlation with tumorigenesis and progression.Medical oncology (Northwood, London, England) · 2012Article
- PTTG1/securin modulates microtubule nucleation and cell migration.Molecular biology of the cell · 2011Article
- Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins.Molecular carcinogenesis · 2011Article
- Glycogen synthase kinase-3beta (GSK3beta) negatively regulates PTTG1/human securin protein stability, and GSK3beta inactivation correlates with securin accumulation in breast tumors.The Journal of biological chemistry · 2011Article
- Pituitary tumor transforming gene-1 haplotypes and risk of pituitary adenoma: a case-control study.BMC medical genetics · 2011Article
- Mitotic chromosomal instability and cancer: mouse modelling of the human disease.Nature reviews. Cancer · 2010Review
- Securin promotes the identification of favourable outcome in invasive breast cancer.British journal of cancer · 2009Article
- Induction of Dlk1 by PTTG1 inhibits adipocyte differentiation and correlates with malignant transformation.Molecular biology of the cell · 2009Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of oncogenes in pituitary tumorigenesis remains elusive since few genetic changes have been identified so far in pituitary tumors. Pituitary tumor-transforming gene (pttg) has been recently cloned from rat GH4 pituitary tumor cells. We have previously isolated and characterized hpttg from human thymus. In the present study, we analyse the expression of hpttg mRNA in a series of human pituitary adenomas. We show that hpttg is highly expressed in the majority of pituitary adenomas while only very low levels of mRNA can be detected in normal pituitary gland by Northern blot analysis. hPTTG protein was immunolocalized mainly in the cytoplasm of adenoma cells. Other common extra-cranial malignant tumors were also analysed by immunohistochemistry. Interestingly, strong hPTTG immunoreactivity was detected in most adenocarcinomas of mammary and pulmonary origins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.