ReviewOncogene1999
Developmental defects and tumor predisposition in Rb mutant mice.
Review in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 78 citations in OpenAlex.
- The tumor suppressor pRb and its relative p130 are required to maintain murine adult skeletal muscle homeostasis.Oncogene · 2025Article
- Article
- Monitoring the Cell Cycle of Tumor Cells in Mouse Models of Human Cancer.Cold Spring Harbor perspectives in medicine · 2023Article
- Transgenic mouse models of breast cancer.Cancer letters · 2021Article
- Preclinical In Vivo Modeling of Pediatric Sarcoma-Promises and Limitations.Journal of clinical medicine · 2021Review
- Hypothesis: Retinoblastoma protein inactivation mediates effects of histone deacetylase inhibitor-induced Wnt hyperactivation in colorectal cancer cells.Journal of Cancer · 2020Article
- Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists.Scientific reports · 2016Article
- E2f8 mediates tumor suppression in postnatal liver development.The Journal of clinical investigation · 2016Article
- RB1: a prototype tumor suppressor and an enigma.Genes & development · 2016Review
- Deletion of Rb1 induces both hyperproliferation and cell death in murine germinal center B cells.Experimental hematology · 2016Article
- GPR41 and GPR43 in Obesity and Inflammation - Protective or Causative?Frontiers in immunology · 2016Review
- E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3.Cell death and differentiation · 2013Article
- Rb suppresses collective invasion, circulation and metastasis of breast cancer cells in CD44-dependent manner.PloS one · 2013Article
- Developing genetically engineered mouse models to study tumor suppression.Current protocols in mouse biology · 2012Article
- Haploinsufficiency of Tumor Suppressor Genes is Driven by the Cumulative Effect of microRNAs, microRNA Binding Site Polymorphisms and microRNA Polymorphisms: An In silico Approach.Cancer informatics · 2012Article
- Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status.The Journal of clinical investigation · 2010Article
- p21(Cip1) restrains pituitary tumor growth.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The retinoblastoma protein is required for Ras-induced oncogenic transformation.Molecular and cellular biology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Targeted gene disruption in the mouse germline permits the introduction of gene mutations similar to those found in inherited human diseases. New advances in gene targeting that enable cell type specific gene disruption in mice further increases the utility of mouse models to study genetic defects as found in cancer. Here we review the phenotypes observed in mice carrying germline mutated copies of the retinoblastoma tumor suppressor gene. We will illustrate how methods that permit tissue-specific Rb inactivation in mice provide new and more versatile tools to gain insight into the etiology of sporadic cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.