ArticleOncogene1999
Identification of human APC10/Doc1 as a subunit of anaphase promoting complex.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Anaphase-Promoting Complex Subunit 1 Associates with Bone Mineral Density in Human Osteoporotic Bone.International journal of molecular sciences · 2023Article
- A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer.Cell cycle (Georgetown, Tex.) · 2019Article
- Network Cluster Analysis of Protein-Protein Interaction Network-Identified Biomarker for Type 2 Diabetes.Diabetes technology & therapeutics · 2015Article
- An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes.Frontiers in microbiology · 2014Review
- Experimental validation of Ankrd17 and Anapc10, two novel meiotic genes predicted by computational models in mice.Biology of reproduction · 2012Article
- GPS-ARM: computational analysis of the APC/C recognition motif by predicting D-boxes and KEN-boxes.PloS one · 2012Article
- Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation.The Journal of cell biology · 2008Article
- Getting in and out of mitosis with Polo-like kinase-1.Oncogene · 2005Review
- Kinetochore localization of spindle checkpoint proteins: who controls whom?Molecular biology of the cell · 2004Article
- Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation.The EMBO journal · 2004Article
- Article
- Cell cycle-dependent degradation of the Saccharomyces cerevisiae spindle motor Cin8p requires APC(Cdh1) and a bipartite destruction sequence.Molecular biology of the cell · 2001Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anaphase-promoting complex or cyclosome (APC) is a ubiquitin ligase which specifically targets mitotic regulatory factors such as Pds1/Cut2 and cyclin B. Identification of the subunits of multiprotein complex APC in several species revealed the highly conserved composition of APC from yeast to human. It has been reported, however, that vertebrate APC is composed of at least eight subunits, APC1 to APC8, while budding yeast APC is constituted of at least 12 components, Apc1 to Apc13. It has not yet been clearly understood whether additional components found in budding yeast, Apc9 to Apc13, are actually composed of mammalian APC. Here we isolated and characterized human APC10/Doc1, and found that APC10/Doc1 binds to APC core subunits throughout the cell cycle. Further, it was found that APC10/Doc1 is localized in centrosomes and mitotic spindles throughout mitosis, while it is also localized in kinetochores from prophase to anaphase and in midbody in telophase and cytokinesis. These results strongly support the notion that human APC10/Doc1 may be one of the APC core subunits rather than the transiently associated regulatory factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.