ArticleJournal of bacteriology1999
Identification of pel, a Streptococcus pyogenes locus that affects both surface and secreted proteins.
Article in Journal of bacteriology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 70 citations in OpenAlex.
- Slipped-strand mispairing within a polycytidine tract in transcriptional regulatorFrontiers in microbiology · 2023Article
- The Regulatory Small RNA MarS Supports Virulence of Streptococcus pyogenes.Scientific reports · 2017Article
- The majority of 9,729 group A streptococcus strains causing disease secrete SpeB cysteine protease: pathogenesis implications.Infection and immunity · 2015Article
- The sagA/pel locus does not regulate the expression of the M protein of the M1T1 lineage of group A Streptococcus.Virulence · 2013Article
- Novel regulatory small RNAs in Streptococcus pyogenes.PloS one · 2013Article
- Streptolysin S-like virulence factors: the continuing sagA.Nature reviews. Microbiology · 2011Review
- Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier.The Journal of biological chemistry · 2011Article
- The group A Streptococcus small regulatory RNA FasX enhances streptokinase activity by increasing the stability of the ska mRNA transcript.Molecular microbiology · 2010Article
- Identification of small RNAs in Francisella tularensis.BMC genomics · 2010Article
- Comparative genome-wide analysis of small RNAs of major Gram-positive pathogens: from identification to application.Microbial biotechnology · 2010Review
- CcpA and LacD.1 affect temporal regulation of Streptococcus pyogenes virulence genes.Infection and immunity · 2010Article
- A genome-wide analysis of small regulatory RNAs in the human pathogen group A Streptococcus.PloS one · 2009Article
- vfr, a novel locus affecting cysteine protease production in Streptococcus pyogenes.Journal of bacteriology · 2009Article
- CcpA-mediated repression of streptolysin S expression and virulence in the group A streptococcus.Infection and immunity · 2008Article
- Role for sagA and siaA in quorum sensing and iron regulation in Streptococcus pyogenes.Infection and immunity · 2007Article
- Identification and characterization of bicistronic speB and prsA gene expression in the group A Streptococcus.Journal of bacteriology · 2006Article
- Analysis of the transcriptome of group A Streptococcus in mouse soft tissue infection.The American journal of pathology · 2006Article
- Effects of oligopeptide permease in group a streptococcal infection.Infection and immunity · 2005Article
- Impact of the SpeB protease on binding of the complement regulatory proteins factor H and factor H-like protein 1 by Streptococcus pyogenes.Infection and immunity · 2005Article
- The M protein is dispensable for maturation of streptococcal cysteine protease SpeB.Infection and immunity · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
A Tn917 insertion mutant of an M49 serotype, opacity factor-positive Streptococcus pyogenes, was isolated. It had the following phenotypes: decreased beta-hemolysis mediated by streptolysin S, reduction in the activity of a secreted cysteine protease and streptokinase, and an altered immunoglobulin and fibrinogen-binding phenotype. The site of insertion of Tn917 into the chromosome and the surrounding sequence, the pel region (pleiotropic effect locus), was determined. Phage A25 transduction confirmed that the pleiotropic changes in phenotype could be cotransduced with Tn917. The pel region was cloned and sequenced, and the transposon was found to be inserted upstream of a single open reading frame which led to a failure to transcribe a 500-base mRNA. The loss of this transcript decreased the transcription of emm and speB genes and reduced the secretion of streptokinase. Enhanced Pel expression from a nisin-inducible plasmid resulted in increased message levels for emm in a wild-type organism. Characterization of the pel mutant provides evidence for the coordinated regulation of secreted and surface proteins and suggests the existence of a new global regulatory factor in S. pyogenes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.