ArticleThe American journal of tropical medicine and hygiene1999
Blood-stage dynamics and clinical implications of mixed Plasmodium vivax-Plasmodium falciparum infections.
Article in The American journal of tropical medicine and hygiene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Plasmodium spp. mixed infection leading to severe malaria: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Evaluating malaria elimination strategies among military forces in Cambodia: a multi-arm clinical trial comparing monthly prophylaxis and focused screening and treatment.BMC infectious diseases · 2025Trial
- Article
- Assessment of the infectivity of malaria parasites from asymptomatic school children to Anopheles gambiae mosquitoes in a high transmission area in Ghana.Scientific reports · 2025Article
- Modeling and investigating malaria P. Falciparum and P. Vivax infections: Application to Djibouti data.Infectious Disease Modelling · 2024Article
- A comparative hospital-based observational study of mono- and co-infections of malaria, dengue virus and scrub typhus causing acute undifferentiated fever.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Observational
- "Asymptomatic" Malaria: A Chronic and Debilitating Infection That Should Be Treated.PLoS medicine · 2016Review
- A simulation model of the within-host dynamics of Plasmodium vivax infection.Malaria journal · 2015Article
- Effective preparation of Plasmodium vivax field isolates for high-throughput whole genome sequencing.PloS one · 2013Article
- Development and evaluation of a rapid diagnostic test for Plasmodium falciparum, P. vivax, and mixed-species malaria antigens.The American journal of tropical medicine and hygiene · 2011Article
- Plasmodium knowlesi Malaria in humans and macaques, Thailand.Emerging infectious diseases · 2011Article
- Immune response to Plasmodium vivax has a potential to reduce malaria severity.Clinical and experimental immunology · 2010Article
- Prevalence of antimalarial drug resistance mutations in Plasmodium vivax and P. falciparum from a malaria-endemic area of Pakistan.The American journal of tropical medicine and hygiene · 2009Article
- The spatial and temporal patterns of falciparum and vivax malaria in Perú: 1994-2006.Malaria journal · 2009Article
- Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection.Malaria journal · 2008Article
- CD4+T cells do not mediate within-host competition between genetically diverse malaria parasites.Proceedings. Biological sciences · 2008Article
- A stochastic model of immune-modulated malaria infection and disease in children.Mathematical biosciences · 2007Article
- Dynamics of immune response and drug resistance in malaria infection.Malaria journal · 2006Article
- Competition for red blood cells can enhance Plasmodium vivax parasitemia in mixed-species malaria infections.The American journal of tropical medicine and hygiene · 2006Article
- Fever in patients with mixed-species malaria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We present a mathematical model of the blood-stage dynamics of mixed Plasmodium vivax-Plasmodium falciparum malaria infections in humans. The model reproduces features of such infections found in nature and suggests several phenomena that may merit clinical attention, including the potential recrudescence of a long-standing, low-level P. falciparum infection following a P. vivax infection or relapse and the capacity of an existing P. vivax infection to reduce the peak parasitemia of a P. falciparum superinfection. We simulate the administration of antimalarial drugs, and illustrate some potential complications in treating mixed-species malaria infections. Notably, our model indicates that when a mixed-species infection is misdiagnosed as a single-species P. vivax infection, treatment for P. vivax can lead to a surge in P. falciparum parasitemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.