ArticleInfection and immunity1999
Complete DNA sequence and structural analysis of the enteropathogenic Escherichia coli adherence factor plasmid.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 134 citations in OpenAlex.
- Genome-Based Epidemiologic Analysis of VIM/IMP Carbapenemase-Producing Enterobacter spp., Poland.Emerging infectious diseases · 2023Article
- Updates on the Virulence Factors Produced by Multidrug-ResistantMicroorganisms · 2023Review
- Virulence Characteristics, Antibiotic Resistance Patterns and Molecular Typing of Enteropathogenic ProducingInfection and drug resistance · 2022Article
- PlasmidFrontiers in molecular biosciences · 2022Article
- The transcriptional activator of the bfp operon in EPEC (PerA) interacts with the RNA polymerase alpha subunit.Scientific reports · 2021Article
- Complete Whole Genome Sequences ofMicroorganisms · 2021Article
- Analysis of the Virulence Profile and Phenotypic Features of Typical and Atypical EnteroaggregativeFrontiers in cellular and infection microbiology · 2020Article
- Review
- Novel type of pilus associated with a Shiga-toxigenic E. coli hybrid pathovar conveys aggregative adherence and bacterial virulence.Emerging microbes & infections · 2018Article
- Going around in circles: virulence plasmids in enteric pathogens.Nature reviews. Microbiology · 2018Review
- Novel Hybrid of Typical EnteropathogenicFrontiers in microbiology · 2018Article
- Characterization of a Large Antibiotic Resistance Plasmid Found in Enteropathogenic Escherichia coli Strain B171 and Its Relatedness to Plasmids of Diverse E. coli and Shigella Strains.Antimicrobial agents and chemotherapy · 2017Article
- Comparative genomics and transcriptomics of Escherichia coli isolates carrying virulence factors of both enteropathogenic and enterotoxigenic E. coli.Scientific reports · 2017Article
- Classes 1 and 2 integrons in faecal Escherichia coli strains isolated from mother-child pairs in Nigeria.PloS one · 2017Article
- Self-Conjugation of the EnteropathogenicBioMed research international · 2017Article
- PerC Manipulates Metabolism and Surface Antigens in EnteropathogenicFrontiers in cellular and infection microbiology · 2017Article
- Diarrheagenic Escherichia coli.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2016Review
- Evidence of Naturalized Stress-Tolerant Strains of Escherichia coli in Municipal Wastewater Treatment Plants.Applied and environmental microbiology · 2016Article
- Genetic analysis of enteropathogenic Escherichia coli (EPEC) adherence factor (EAF) plasmid reveals a new deletion within the EAF probe sequence among O119 typical EPEC strains.BMC microbiology · 2015Article
- Comparative Genomics Provides Insight into the Diversity of the Attaching and Effacing Escherichia coli Virulence Plasmids.Infection and immunity · 2015Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complete nucleotide sequence and organization of the enteropathogenic Escherichia coli (EPEC) adherence factor (EAF) plasmid of EPEC strain B171 (O111:NM) were determined. The EAF plasmid encodes two known virulence-related operons, the bfp operon, which is composed of genes necessary for biosynthesis of bundle-forming pili, and the bfpTVW (perABC) operon, composed of regulatory genes required for bfp transcription and also for transcriptional activation of the eae gene in the LEE pathogenicity island on the EPEC chromosome. The 69-kb EAF plasmid, henceforth designated pB171, contains, besides the bfp and bfpTVW (perABC) operons, potential virulence-associated genes, plasmid replication and maintenance genes, and many insertion sequence elements. Of the newly identified open reading frames (ORFs), two which comprise a single operon had the potential to encode proteins with high similarity to a C-terminal region of ToxB whose coding sequence is located on pO157, a large plasmid harbored by enterohemorrhagic E. coli. Another ORF, located between the bfp and bfpTVW operons, showed high similarity with trcA, a bfpT-regulated chaperone-like protein gene of EPEC. Two sites were found to be putative replication regions: one similar to RepFIIA of p307 or F, and the other similar to RepFIB of R100 (NR1). In addition, we identified a third region that contains plasmid maintenance genes. Insertion elements were scattered throughout the plasmid, indicating the mosaic nature of the EAF plasmid and suggesting evolutionary events by which virulence genes may have been obtained.
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