ArticleInfection and immunity1999
Trapping and immobilization of Nippostrongylus brasiliensis larvae at the site of inoculation in primary infections of interleukin-5 transgenic mice.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Disruption of the C5a/C5aR1 axis confers protection against hookworm infection in lung.Frontiers in immunology · 2024Article
- Examination of Horizontal Transmission ofJournal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- Th2-dependent STAT6-regulated genes in intestinal epithelial cells mediate larval trapping during secondary Heligmosomoides polygyrus bakeri infection.PLoS pathogens · 2023Article
- Tissue-specific immunity in helminth infections.Mucosal immunology · 2022Review
- β-Glucan receptors on IL-4 activated macrophages are required for hookworm larvae recognition and trapping.Immunology and cell biology · 2022Article
- Intestinal eosinophils: multifaceted roles in tissue homeostasis and disease.Seminars in immunopathology · 2021Review
- Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection.Cell host & microbe · 2021Article
- Detection of α-defensin in eosinophils in helminth-infected mouse model.The Journal of veterinary medical science · 2018Article
- ILC2s in infectious diseases and organ-specific fibrosis.Seminars in immunopathology · 2018Review
- Role of basophils in protective immunity to parasitic infections.Seminars in immunopathology · 2016Review
- Antibody-mediated trapping of helminth larvae requires CD11b and Fcγ receptor I.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Host protective roles of type 2 immunity: parasite killing and tissue repair, flip sides of the same coin.Seminars in immunology · 2014Review
- Systemic impact of intestinal helminth infections.Mucosal immunology · 2014Review
- Hookworm-related cutaneous larva migrans in patients living in an endemic community in Brazil: immunological patterns before and after ivermectin treatmen.European journal of microbiology & immunology · 2013Article
- Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection.Frontiers in immunology · 2013Article
- The lung is an important site for priming CD4 T-cell-mediated protective immunity against gastrointestinal helminth parasites.Infection and immunity · 2010Article
- Inactivation of the complement anaphylatoxin C5a by secreted products of parasitic nematodes.International journal for parasitology · 2010Article
- FVB/N mice are highly resistant to primary infection with Nippostrongylus brasiliensis.Parasitology · 2009Article
- Role of eosinophils and neutrophils in innate and adaptive protective immunity to larval strongyloides stercoralis in mice.Infection and immunity · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-5 (IL-5) transgenic mice are highly resistant to primary infections with the intestinal nematode Nippostrongylus brasiliensis; few parasites are found in the intestines of infected animals, and egg production is minimal. While adult worms may be damaged in the intestine, larval migration, development, and viability may also be impaired in other tissues. This study addresses the migration of N. brasiliensis larvae through the skin and lungs and associated cellular responses in primary infections of IL-5 transgenic mice. Although some larvae may have been trapped and killed in the lungs of IL-5 transgenic mice, most apparently failed to reach this site. Two or more hours after infection of IL-5 transgenic mice, eosinophils were a major component of the cellular infiltrate at the subcutaneous site of injection, and localized eosinophil degranulation was extensive. Seventy-five to ninety-five percent of the larvae injected into subcutaneous air pouches in IL-5 transgenic mice were retained there for at least 24 h. In contrast, in nontransgenic mice, less than 20% of larvae could be recovered from the skin 2 or more h postinjection, and eosinophil activity was modest at all times. The data strongly suggest that eosinophils can restrict the movement of N. brasiliensis larvae in the first few hours of a primary infection and that this has profound effects on later stages of parasite development. Preexisting eosinophilia, due either to allergy or to infection with tissue-invasive helminth species, may therefore confer some degree of immediate and nonspecific resistance in primary infections with parasitic worms.
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