ArticleInfection and immunity1999
Development and characterization of a Staphylococcus aureus nasal colonization model in mice.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed.
- Probiotic for pathogen-specific Staphylococcus aureus decolonisation in Thailand: a phase 2, double-blind, randomised, placebo-controlled trial.The Lancet. Microbe · 2023Trial
- The administration of intranasal live attenuated influenza vaccine induces changes in the nasal microbiota and nasal epithelium gene expression profiles.Microbiome · 2015Trial
- Constitutive production of catalytic antibodies to a Staphylococcus aureus virulence factor and effect of infection.The Journal of biological chemistry · 2012Trial
- Key role for clumping factor B in Staphylococcus aureus nasal colonization of humans.PLoS medicine · 2008Trial
- Examining the role of IgA in a persistent model of Staphylococcus aureus colonization.PLoS pathogens · 2026Article
- Integrated genomic and proteomic analysis of the mouse-adaptedCurrent research in microbial sciences · 2025Article
- An exploration of mechanisms underlyingmSphere · 2024Article
- Selection ofFrontiers in cellular and infection microbiology · 2022Article
- Discovery ofMicroorganisms · 2021Article
- Murine Model of Sinusitis Infection for Screening Antimicrobial and Immunomodulatory Therapies.Frontiers in cellular and infection microbiology · 2021Article
- Review
- Article
- Staphylococci: Evolving Genomes.Microbiology spectrum · 2019Review
- Sortases, Surface Proteins, and Their Roles inMicrobiology spectrum · 2019Article
- Staphylococcal Protein A Contributes to Persistent Colonization of Mice with Staphylococcus aureus.Journal of bacteriology · 2018Article
- The commensal lifestyle of Staphylococcus aureus and its interactions with the nasal microbiota.Nature reviews. Microbiology · 2017Review
- Development of persistent gastrointestinal S. aureus carriage in mice.Scientific reports · 2017Article
- Global transcriptome responses including small RNAs during mixed-species interactions with methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa.MicrobiologyOpen · 2017Article
- Laboratory Mice Are Frequently Colonized withFrontiers in cellular and infection microbiology · 2017Article
- The role of two branched-chain amino acid transporters in Staphylococcus aureus growth, membrane fatty acid composition and virulence.Molecular microbiology · 2016Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Staphylococcus aureus nasal carriage is a risk factor for infection in humans, particularly in the hospital environment. Attenuation of carriage has proven effective in reducing the prevalence of infection in some high-risk groups. To study staphylococcal factors that influence nasal colonization, a mouse model of S. aureus nasal colonization was developed. Mice were inoculated intranasally with S. aureus Reynolds, and nasal carriage was evaluated by quantitating cultures of the nasal tissues from mice sacrificed at various time points after inoculation. The majority of mice inoculated with 10(8) CFU of S. aureus maintained nasal carriage for at least 20 days. Nasal colonization rates were similar for inbred (BALB/c and C57BL/6) and outbred (ICR) mice. Colonization was not affected by mouse passage of strain Reynolds. Lower inoculum doses (<10(7) CFU) resulted in reduced colonization after 7 days. However, mice given streptomycin in their drinking water developed long-term carriage of S. aureus, and they were colonized with inocula as low as 10(5) CFU. Nasal colonization was also established with two other S. aureus strains (one strain each of human and murine origins). S. aureus recovered from the nares of experimentally colonized mice expressed high levels of capsule, and the ability of a capsule-defective mutant to persist in the nares was reduced in comparison to that of the parent strain. This nasal colonization model should prove useful for studies of factors that mediate S. aureus colonization and for assessment of targets for antimicrobial intervention or vaccine development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.