ReviewPharmaceutical research1999
Intestinal peptide transport systems and oral drug availability.
Review in Pharmaceutical research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 163 citations in OpenAlex.
- Effect and Mechanism of Theaflavins on Fluoride Transport and Absorption in Caco-2 Cells.Foods (Basel, Switzerland) · 2023Article
- An emerging role of vitamin DAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- The evolution of nucleosidic analogues: self-assembly of prodrugs into nanoparticles for cancer drug delivery.Nanoscale advances · 2021Review
- Discovery of Dipeptides as Potent Botulinum Neurotoxin A Light-Chain Inhibitors.ACS medicinal chemistry letters · 2021Article
- Synthesis of a new fluorescent analogue of proglyprol and study of the mechanisms of its transport into the cultured rat pheochromocytoma cells.Doklady. Biochemistry and biophysics · 2015Article
- Preclinical absorption, distribution, metabolism, and excretion of an oral amide prodrug of gemcitabine designed to deliver prolonged systemic exposure.Pharmaceutics · 2013Article
- Immunocytochemistry for amoxicillin and its use for studying uptake of the drug in the intestine, liver, and kidney of rats.Antimicrobial agents and chemotherapy · 2011Article
- ABC and SLC transporter expression and proton oligopeptide transporter (POT) mediated permeation across the human blood--brain barrier cell line, hCMEC/D3 [corrected].Molecular pharmaceutics · 2010Article
- Scientific Opinion on the safety of 'sardine Peptide Product'.EFSA journal. European Food Safety Authority · 2010Article
- Modeling kinetics of subcellular disposition of chemicals.Chemical reviews · 2009Review
- Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats.Pharmaceutical research · 2009Article
- Pharmacokinetics of Stereoisomeric Dipeptide Prodrugs of Acyclovir Following Intravenous and Oral Administrations in Rats: A Study Involving In vivo Corneal Uptake of Acyclovir Following Oral Dosing.Ophthalmology and eye diseases · 2009Article
- Artificial neural network models for prediction of intestinal permeability of oligopeptides.BMC bioinformatics · 2007Article
- Prediction of glycylsarcosine transport in Caco-2 cell lines expressing PEPT1 at different levels.Pflugers Archiv : European journal of physiology · 2006Article
- In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors.Pharmaceutical research · 2005Article
- The prediction of human oral absorption for diffusion rate-limited drugs based on heuristic method and support vector machine.Journal of computer-aided molecular design · 2005Article
- Small bowel review: Normal physiology, part 1.Digestive diseases and sciences · 2003Review
- Inhibition of intestinal dipeptide transport by the neuropeptide VIP is an anti-absorptive effect via the VPAC1 receptor in a human enterocyte-like cell line (Caco-2).British journal of pharmacology · 2003Article
- PepT1 mRNA expression is induced by starvation and its level correlates with absorptive transport of cefadroxil longitudinally in the rat intestine.Pharmaceutical research · 2002Article
- PKQuest: capillary permeability limitation and plasma protein binding - application to human inulin, dicloxacillin and ceftriaxone pharmacokinetics.BMC clinical pharmacology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestinal peptide transport system has broad substrate specificities. In addition to its physiological function of absorbing di- and tripeptides resulting from the digestion of dietary proteins, this transport system also absorbs some orally administered peptidomimetic drugs, including beta-lactam antibiotics, angiotensin converting enzyme inhibitors, renin inhibitors, bestatin, thrombin inhibitors, and thyrotropin-releasing hormone and its analogues. There have been several studies on the mechanism and substrate structure-affinity relationship for this transport system. Rapid progress has been made recently in studies on the molecular basis of the intestinal peptide transport system. A protein apparently involved in peptide transport has been isolated from rabbit small intestines, and genes for human intestinal peptide transporters have been cloned, sequenced and functionally expressed. This review summarizes these studies and addresses the pharmaceutical potential of the intestinal peptide transport system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.