ArticleBritish journal of cancer1999
Proteolysis in human breast and colorectal cancer.
Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 85 citations in OpenAlex.
- Comprehensive investigation of matrix metalloproteinases in skin cutaneous melanoma: diagnostic, prognostic, and therapeutic insights.Scientific reports · 2025Article
- TiAnalytical and bioanalytical chemistry · 2024Article
- Identification and Characterization of an HtrA Sheddase Produced byInternational journal of molecular sciences · 2023Article
- Evaluation of chemotherapy with nanosomal paclitaxel and gene therapy expressing apoptosis-inducing proteins in the management of spontaneous canine mammary neoplasm.Journal of stem cells & regenerative medicine · 2019Article
- Single Molecule Nanopore Spectrometry for Peptide Detection.ACS sensors · 2017Article
- Role of MMP-2 (-1306 C/T) Polymorphism in Pituitary Adenoma.Scientifica · 2016Article
- Evaluation of a triple-helical peptide with quenched FluorSophores for optical imaging of MMP-2 and MMP-9 proteolytic activity.Molecules (Basel, Switzerland) · 2014Article
- Assessing the value of matrix metalloproteinase 9 (MMP9) in improving the appropriateness of referrals for colorectal cancer.British journal of cancer · 2013Article
- Serum matrix metalloproteinase 9 and colorectal neoplasia: a community-based evaluation of a potential diagnostic test.British journal of cancer · 2012Article
- Soluble E-cadherin: more than a symptom of disease.Frontiers in bioscience (Landmark edition) · 2012Review
- [Advances of the correlation between JAK-STAT3 signaling pathway and the biological behavior of non-small cell lung cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2010Review
- Active MMP-2 effectively identifies the presence of colorectal cancer.International journal of cancer · 2009Article
- Formulation and characterization of injectable poly(DL-lactide-co-glycolide) implants loaded with N-acetylcysteine, a MMP inhibitor.Pharmaceutical research · 2008Article
- Evaluation of the accuracy of serum MMP-9 as a test for colorectal cancer in a primary care population.BMC cancer · 2006Article
- A prospective study to assess the value of MMP-9 in improving the appropriateness of urgent referrals for colorectal cancer.BMC cancer · 2006Article
- Reduced nonprotein thiols inhibit activation and function of MMP-9: implications for chemoprevention.Free radical biology & medicine · 2006Article
- Zymographic detection and clinical correlations of MMP-2 and MMP-9 in breast cancer sera.British journal of cancer · 2004Article
- Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression.Breast cancer research : BCR · 2004Article
- Matrix metalloproteinase-2 (MMP-2) is associated with survival in breast carcinoma.British journal of cancer · 2003Article
- Role of genetic polymorphisms in tumour angiogenesis.British journal of cancer · 2002Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteolysis occurs when proteinase activity exceeds inhibitor activity. Proteolysis is normally tightly regulated and is involved in cancer invasion and metastasis. The aim of this study was to compare proteolysis in breast and colorectal cancer. Proteinase and inhibitor expression were analysed in paired tumour and normal tissue samples from 43 breast and 24 colorectal cancer patients using substrate zymography, Western blotting and quenched fluorescence substrate hydrolysis. The expression of the latent forms of matrix metalloproteinase-2 (MMP-2), MMP-3 and MMP-9, urokinase plasminogen activator (uPA), tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression were observed in both tumour and normal tissue samples from breast and colorectal tissue; however, expression was greater in the tumour tissue. Expression of active MMP-2 and MMP-9 and the total MMP activity were greater in tumour compared to normal samples in both tissues (P < 0.05). The expression of all proteinases and total MMP activity was greater in colorectal tissue than breast tissue samples. Breast and colorectal cancer demonstrated different proteinase profiles, however proteolysis in both tissues was greater in tumour tissue than normal tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.