ArticleThe Biochemical journal1999
Pathway alignment: application to the comparative analysis of glycolytic enzymes.
Article in The Biochemical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- The return of metabolism: biochemistry and physiology of glycolysis.Biological reviews of the Cambridge Philosophical Society · 2026Review
- The early evolution of the glycolytic pathway from autotrophic origins to glycogen and back.FEMS microbiology reviews · 2025Review
- Structure function analysis of ADP-dependent cyanobacterial phosphofructokinase reveals new phylogenetic grouping in the PFK-A family.The Journal of biological chemistry · 2024Article
- Tracing the phylogenetic history of the Crl regulon through the Bacteria and Archaea genomes.BMC genomics · 2019Article
- Unlocking conserved and diverged metabolic characteristics in cassava carbon assimilation via comparative genomics approach.Scientific reports · 2018Article
- Standard Gibbs Energy of Metabolic Reactions: III The 3-Phosphoglycerate Kinase Reaction.ACS omega · 2018Article
- Metabolic pathway reconstruction strategies for central metabolism and natural product biosynthesis.Biophysics and physicobiology · 2016Review
- The alignment of enzymatic steps reveals similar metabolic pathways and probable recruitment events in Gammaproteobacteria.BMC genomics · 2015Article
- A new network representation of the metabolism to detect chemical transformation modules.BMC bioinformatics · 2015Article
- A Minimal Set of Glycolytic Genes Reveals Strong Redundancies in Saccharomyces cerevisiae Central Metabolism.Eukaryotic cell · 2015Article
- Constraint-based models predict metabolic and associated cellular functions.Nature reviews. Genetics · 2014Review
- Topology of molecular interaction networks.BMC systems biology · 2013Review
- Supervised de novo reconstruction of metabolic pathways from metabolome-scale compound sets.Bioinformatics (Oxford, England) · 2013Article
- Modular architecture of metabolic pathways revealed by conserved sequences of reactions.Journal of chemical information and modeling · 2013Article
- Organism-adapted specificity of the allosteric regulation of pyruvate kinase in lactic acid bacteria.PLoS computational biology · 2013Article
- Computational model for pathway reconstruction to unravel the evolutionary significance of melanin synthesis.Bioinformation · 2013Article
- Synthetic metabolic engineering-a novel, simple technology for designing a chimeric metabolic pathway.Microbial cell factories · 2012Article
- KOMODO: a web tool for detecting and visualizing biased distribution of groups of homologous genes in monophyletic taxa.Nucleic acids research · 2012Article
- Metabolic network alignment in large scale by network compression.BMC bioinformatics · 2012Article
- Evolutionary plasticity determination by orthologous groups distribution.Biology direct · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comparative analysis of metabolic pathways in different genomes yields important information on their evolution, on pharmacological targets and on biotechnological applications. In this study on glycolysis, three alternative ways of comparing biochemical pathways are combined: (1) analysis and comparison of biochemical data, (2) pathway analysis based on the concept of elementary modes, and (3) a comparative genome analysis of 17 completely sequenced genomes. The analysis reveals a surprising plasticity of the glycolytic pathway. Isoenzymes in different species are identified and compared; deviations from the textbook standard are detailed. Several potential pharmacological targets and by-passes (such as the Entner-Doudoroff pathway) to glycolysis are examined and compared in the different species. Archaean, bacterial and parasite specific adaptations are identified and described.
Indexed as
Identifiers
10493919PMC1220531What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.