ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed.
- Bufalin-Induced Epithelial-to-Mesenchymal Transition in Kidney Epithelial Cells.Cell biology international · 2025Article
- Variable bioenergetic sensitivity of neurons and astrocytes to insulin and extracellular glucose.npj metabolic health and disease · 2024Article
- Modulation of L-type calcium channels in Alzheimer's disease: A potential therapeutic target.Computational and structural biotechnology journal · 2023Review
- Novel calcium-related targets of insulin in hippocampal neurons.Neuroscience · 2017Article
- Analysis of gene expression during aging of CGNs in culture: implication of SLIT2 and NPY in senescence.Age (Dordrecht, Netherlands) · 2015Article
- Functional consequences of age-related morphologic changes to pyramidal neurons of the rhesus monkey prefrontal cortex.Journal of computational neuroscience · 2015Article
- Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons.Molecular psychiatry · 2015Article
- Ethanol alters calcium signaling in axonal growth cones.Neuroscience · 2011Article
- LAT1 overexpression and function compensates downregulation of ASCT2 in an in vitro model of renal proximal tubule cell ageing.Molecular and cellular biochemistry · 2011Article
- Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility.Pigment cell & melanoma research · 2011Article
- Integrating multiple aspects of mitochondrial dynamics in neurons: age-related differences and dynamic changes in a chronic rotenone model.Neurobiology of disease · 2011Article
- Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate release.Journal of neurophysiology · 2006Article
- Dynamic regulation of glycinergic input to spinal dorsal horn neurones by muscarinic receptor subtypes in rats.The Journal of physiology · 2006Article
- Overexpression of Na(+)/K (+)-ATPase parallels the increase in sodium transport and potassium recycling in an in vitro model of proximal tubule cellular ageing.The Journal of membrane biology · 2006Article
- Normal brain ageing: models and mechanisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons.British journal of pharmacology · 2005Article
- Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture.Neuroscience · 2002Article
- Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The membrane density of L-type voltage-sensitive Ca(2+) channels (L-VSCCs) of rat hippocampal neurons increases over age [days in vitro (DIV)] in long-term primary cultures, apparently contributing both to spontaneous cell death and to enhanced excitotoxic vulnerability. Similar increases in L-VSCCs occur during brain aging in vivo in rat and rabbit hippocampal neurons. However, unraveling both the molecular basis and the functional implications of these age changes in VSCC density will require determining whether the other types of high-threshold VSCCs (e.g., N, P/Q, and R) also exhibit altered density and/or changes in regulation, for example, by the important G-protein-coupled, membrane-delimited inhibitory pathway. These possibilities were tested here in long-term hippocampal cultures. Pharmacologically defined whole-cell currents were corrected for cell size differences over age by normalization with whole-cell capacitance. The Ca(2+) channel current density (picoamperes per picofarad), mediated by each Ca(2+) channel type studied here (L, N, and a combined P/Q + R component), increased through 7 DIV. Thereafter, however, only L-type current density continued to increase, at least through 21 DIV. Concurrently, pertussis toxin-sensitive G-protein-coupled inhibition of non-L-type Ca(2+) channel current induced by the GABA(B) receptor agonist baclofen or by guanosine 5'-3-O-(thio)triphosphate declined dramatically with age in culture. Thus, the present studies identify selective and novel parallel mechanisms for the time-dependent alteration of Ca(2+) influx, which could importantly influence function and vulnerability during development and/or aging.
Indexed as
Identifiers
10493768PMC6783042What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.