ArticleProtein science : a publication of the Protein Society1999
Predicting conformational switches in proteins.
Article in Protein science : a publication of the Protein Society, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 73 citations in OpenAlex.
- Protein Fold Usages in Ribosomes: Another Glance to the Past.International journal of molecular sciences · 2024Article
- Prediction and confirmation of a switch-like region within the N-terminal domain of hSIRT1.Biochemistry and biophysics reports · 2022Article
- Inaccurate secondary structure predictions often indicate protein fold switching.Protein science : a publication of the Protein Society · 2019Article
- Comprehensive analysis of sequences of a protein switch.Protein science : a publication of the Protein Society · 2016Article
- Extracting knowledge from protein structure geometry.Proteins · 2013Article
- Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma.Nature medicine · 2013Article
- Nuclear localization of clathrin involves a labile helix outside the trimerization domain.FEBS letters · 2013Article
- Prediction of protein motions from amino acid sequence and its application to protein-protein interaction.BMC structural biology · 2010Article
- A sequence-based hybrid predictor for identifying conformationally ambivalent regions in proteins.BMC genomics · 2009Article
- Predicting continuous local structure and the effect of its substitution for secondary structure in fragment-free protein structure prediction.Structure (London, England : 1993) · 2009Article
- Prion protein misfolding.Current molecular medicine · 2009Review
- FlexPred: a web-server for predicting residue positions involved in conformational switches in proteins.Bioinformation · 2008Article
- Prediction of protein continuum secondary structure with probabilistic models based on NMR solved structures.BMC bioinformatics · 2006Article
- A peptide with alternating lysines can act as a highly specific Z-DNA binding domain.Nucleic acids research · 2006Article
- The effect of long-range interactions on the secondary structure formation of proteins.Protein science : a publication of the Protein Society · 2005Article
- Comparative computational analysis of prion proteins reveals two fragments with unusual structural properties and a pattern of increase in hydrophobicity associated with disease-promoting mutations.Protein science : a publication of the Protein Society · 2004Article
- The PredictProtein server.Nucleic acids research · 2004Article
- On the properties and sequence context of structurally ambivalent fragments in proteins.Protein science : a publication of the Protein Society · 2003Article
- The PredictProtein server.Nucleic acids research · 2003Article
- Environmentally induced reversible conformational switching in the yeast cell adhesion protein alpha-agglutinin.Protein science : a publication of the Protein Society · 2001Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We describe a new computational technique to predict conformationally switching elements in proteins from their amino acid sequences. The method, called ASP (Ambivalent Structure Predictor), analyzes results from a secondary structure prediction algorithm to identify regions of conformational ambivalence. ASP identifies ambivalent regions in 16 test protein sequences for which function involves substantial backbone rearrangements. In the test set, all sites previously described as conformational switches are correctly predicted to be structurally ambivalent regions. No such regions are predicted in three negative control protein sequences. ASP may be useful as a guide for experimental studies on protein function and motion in the absence of detailed three-dimensional structural data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.