ReviewImmunologic research1999
MHC class I restricted T cell responses to Listeria monocytogenes, an intracellular bacterial pathogen.
Review in Immunologic research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Engineering commensal microbes for host health.Cell host & microbe · 2026Review
- Dendritic cell vaccine therapy for colorectal cancer.Pharmacological research · 2021Review
- Review
- Listeriolysin O as a strong immunogenic molecule for the development of new anti-tumor vaccines.Human vaccines & immunotherapeutics · 2013Review
- Single chain MHC I trimer-based DNA vaccines for protection against Listeria monocytogenes infection.Vaccine · 2012Article
- Innate-like CD4 T cells selected by thymocytes suppress adaptive immune responses against bacterial infections.Open journal of immunology · 2012Article
- Listeriolysin O secreted by Listeria monocytogenes into the host cell cytosol is degraded by the N-end rule pathway.Infection and immunity · 2007Article
- Tissue-specific regulation of CD8+ T-lymphocyte immunodominance in respiratory syncytial virus infection.Journal of virology · 2007Article
- Conditional lethality yields a new vaccine strain of Listeria monocytogenes for the induction of cell-mediated immunity.Infection and immunity · 2005Article
- Chlamydia trachomatis-specific human CD8+ T cells show two patterns of antigen recognition.Infection and immunity · 2004Article
- Delayed clearance of Ehrlichia chaffeensis infection in CD4+ T-cell knockout mice.Infection and immunity · 2004Article
- Cross-presentation in viral immunity and self-tolerance.Nature reviews. Immunology · 2001Review
- Systemic immunity and mucosal immunity are induced against human immunodeficiency virus Gag protein in mice by a new hyperattenuated strain of Listeria monocytogenes.Journal of virology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies of the murine immune response to infection with the intracellular bacterial pathogen Listeria monocytogenes have provided a wealth of information about innate and acquired immune defenses in the setting of an infectious disease. Our studies have focused on the MHC class I restricted, CD8+ T cell responses of Balb/c mice to L. monocytogenes infection. Four peptides that derive from proteins that L. monocytogenes secretes into the cytosol of infected cells are presented to cytotoxic T lymphocyte (CTL) by the H2-Kd major histocompatibility complex (MHC) class I molecule. We have found that bacterially secreted proteins are rapidly degraded in the host cell cytosol by proteasomes that utilize, at least in part, the N-end rule to determine the rate of degradation. The MHC class I antigen processing pathway is remarkably efficient at generating peptides that bind to MHC class I molecules. The magnitude of in vivo T cell responses, however, is influenced to only a small degree by the amount of antigen or the efficiency of antigen presentation. Measurements of in vivo T cell expansion following L. monocytogenes infection indicate that differences in the sizes of peptide-specific T cell responses are more likely owing to differences in the repertoire of naive T cells than to differences in peptide presentation. This notion is supported by our additional finding that dominant T cell populations express a more diverse T cell receptor (TCR) repertoire than do subdominant T cell populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.