ArticleDigestive diseases and sciences1999
An autopsy case of malignant mesothelioma with osseous and cartilaginous differentiation: bone morphogenetic protein-2 in mesothelial cells and its tumor.
Article in Digestive diseases and sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Clinical significance of histologic subtyping of malignant pleural mesothelioma.Translational lung cancer research · 2020Review
- Essentials for Pathological Evaluation of Peritoneal Surface Malignancies and Synoptic Reporting of Cytoreductive Surgery Specimens-A review and evidence-based guide.Indian journal of surgical oncology · 2020Review
- BMP2 and VEGF165 transfection to bone marrow stromal stem cells regulate osteogenic potential in vitro.Medicine · 2018Observational
- A Subset of Malignant Mesothelioma Tumors Retain Osteogenic Potential.Scientific reports · 2016Article
- A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2.Tissue engineering. Part B, Reviews · 2016Review
- The effects of α-zearalanol on the proliferation of bone-marrow-derived mesenchymal stem cells and their differentiation into osteoblasts.Journal of bone and mineral metabolism · 2016Article
- Effects of BMP2 and VEGF165 on the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells.Experimental and therapeutic medicine · 2014Article
- The osteogenic study of tissue engineering bone with BMP2 and BMP7 gene-modified rat adipose-derived stem cell.Journal of biomedicine & biotechnology · 2012Article
- Mesothelial cell differentiation into osteoblast- and adipocyte-like cells.Journal of cellular and molecular medicine · 2011Article
- A case of biphasic mesothelioma with osseous and chondromatous differentiation in a cat.The Canadian veterinary journal = La revue veterinaire canadienne · 2011Article
- Experimental construction of BMP2 and VEGF gene modified tissue engineering bone in vitro.International journal of molecular sciences · 2011Article
- The Yin and Yang of bone morphogenetic proteins in cancer.Cytokine & growth factor reviews · 2010Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
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Abstract
An autopsy case of biphasic malignant mesothelioma with osseous and cartilaginous differentiation diffusely involving the peritoneal cavity was confirmed by light microscopic histochemistry, immunohistochemistry, and electron microscopy. A reverse transcription-polymerase chain reaction using specific primers for bone morphogenetic protein-2 (BMP-2) revealed weak positive transcript in normal mesothelial cells and up-regulated expression around bone-forming malignant mesothelioma tissue. However, BMP-2 protein expression was detected only in the marginal zone of bone trabeculae and spindle-shaped mesothelioma cells distributed around bone trabeculae in tumor tissue. The distribution of type IV collagen in tumor tissue was in accordance with the BMP-2 expression. Normal mesothelial cells and tumor cells expressed BMP-2 mRNA, but the BMP-2 protein expression was restricted to the bone-forming area in the malignant mesothelioma.
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