ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Trophic factor-induced plasticity of synaptic connections between identified Lymnaea neurons.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Dopamine-mediated calcium channel regulation in synaptic suppression in L. stagnalis interneurons.Channels (Austin, Tex.) · 2018Article
- The role of retinoic acid in the formation and modulation of invertebrate central synapses.Journal of neurophysiology · 2017Article
- Trophic factor-induced activity 'signature' regulates the functional expression of postsynaptic excitatory acetylcholine receptors required for synaptogenesis.Scientific reports · 2015Article
- In vitro studies of neuronal networks and synaptic plasticity in invertebrates and in mammals using multielectrode arrays.Neural plasticity · 2015Review
- Molluscan neurons in culture: shedding light on synapse formation and plasticity.Journal of molecular histology · 2012Review
- Lidocaine treatment during synapse reformation periods permanently inhibits NGF-induced excitation in an identified reconstructed synapse of Lymnaea stagnalis.Journal of anesthesia · 2012Article
- From understanding cellular function to novel drug discovery: the role of planar patch-clamp array chip technology.Frontiers in pharmacology · 2011Article
- Quercetin targets cysteine string protein (CSPalpha) and impairs synaptic transmission.PloS one · 2010Article
- Trophic factor-induced intracellular calcium oscillations are required for the expression of postsynaptic acetylcholine receptors during synapse formation between Lymnaea neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Transient electrical coupling delays the onset of chemical neurotransmission at developing synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Synaptogenesis in the CNS: an odyssey from wiring together to firing together.The Journal of physiology · 2003Review
- Synapse number and synaptic efficacy are regulated by presynaptic cAMP and protein kinase A.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Development of Ca2+ hotspots between Lymnaea neurons during synaptogenesis.The Journal of physiology · 2002Article
- Trophic factor-induced excitatory synaptogenesis involves postsynaptic modulation of nicotinic acetylcholine receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Article
- Long-term memory survives nerve injury and the subsequent regeneration process.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotrophic factors participate in both developmental and adult synaptic plasticity; however, the underlying mechanisms remain unknown. Using soma-soma synapses between the identified Lymnaea neurons, we demonstrate that the brain conditioned medium (CM)-derived trophic factors are required for the formation of excitatory but not the inhibitory synapse. Specifically, identified presynaptic [right pedal dorsal 1 (RPeD1) and visceral dorsal 4 (VD4)] and postsynaptic [visceral dorsal 2/3 (VD2/3) and left pedal dorsal 1 (LPeD1)] neurons were soma-soma paired either in the absence or presence of CM. We show that in defined medium (DM-does not contain extrinsic trophic factors), appropriate excitatory synapses failed to develop between RPeD1 and VD2/3. Instead, inappropriate inhibitory synapses formed between VD2/3 and RPeD1. Similarly, mutual inhibitory synapses developed between VD4 and LPeD1 in DM. These inhibitory synapses were termed novel because they do not exist in the intact brain. To test whether DM-induced, inappropriate inhibitory synapses could be corrected by the addition of CM, cells were first paired in DM for an initial period of 12 hr. DM was then replaced with CM, and simultaneous intracellular recordings were made from paired cells after 6-12 hr of CM substitution. Not only did CM induce the formation of appropriate excitatory synapses between both cell pairs, but it also reduced the incidence of inappropriate inhibitory synapse formation. The CM-induced plasticity of synaptic connections involved new protein synthesis and transcription and was mediated via receptor tyrosine kinases. Taken together, our data provide the first direct insight into the cellular mechanism underlying trophic factor-induced specificity and plasticity of synaptic connections between soma-soma paired Lymnaea neurons.
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10492012PMC311294W1884598502What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.