ArticleOncogene1999
Comparative structure and characterization of a CDKN2 gene in a Xiphophorus fish melanoma model.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 54 citations in OpenAlex.
- Validity of Xiphophorus fish as models for human disease.Disease models & mechanisms · 2024Review
- Xmrks the Spot: Fish Models for Investigating Epidermal Growth Factor Receptor Signaling in Cancer Research.Cells · 2021Review
- Oncogenic allelic interaction inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Spontaneously occurring melanoma in animals and their relevance to human melanoma.The Journal of pathology · 2020Review
- Analysis of the putative tumor suppressor gene cdkn2ab in pigment cells and melanoma of Xiphophorus and medaka.Pigment cell & melanoma research · 2019Article
- Comparison of Xiphophorus and human melanoma transcriptomes reveals conserved pathway interactions.Pigment cell & melanoma research · 2018Article
- Molecular genetic analysis of the melanoma regulatory locus in Xiphophorus interspecies hybrids.Molecular carcinogenesis · 2017Article
- Ephemeral association between gene CG5762 and hybrid male sterility in Drosophila sibling species.Journal of molecular evolution · 2011Article
- Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle.Cell stem cell · 2010Article
- Genetic and environmental melanoma models in fish.Pigment cell & melanoma research · 2010Review
- Etiology of MNU-induced melanomas in Xiphophorus hybrids.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2009Article
- Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.Nature reviews. Molecular cell biology · 2006Review
- A microsatellite genetic linkage map for Xiphophorus.Genetics · 2004Article
- Absence of p16INK4a and truncation of ARF tumor suppressors in chickens.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- One INK4 gene and no ARF at the Fugu equivalent of the human INK4A/ARF/INK4B tumour suppressor locus.Oncogene · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We have cloned, sequenced, and characterized the RNA expression properties of a fish CDKN2 gene from Xiphophorus helleri and X. maculatus. This gene, termed CDKN2X, shows a high degree of amino acid sequence similarity to members of the mammalian CDKN2 gene family, which includes the tumor suppressor loci CDKN2A (P16) and CDKN2B (P15). Comparative sequence analysis suggests that fish CDKN2X is similarly related to all four mammalian gene family members, and may represent a descendant of an ancestral prototypic CDKN2 gene. CDKN2X was mapped to a region on autosomal Xiphophorus linkage group V (LG V) known to contain the DIFF gene that acts as a tumor suppressor of melanoma formation in X. helleri/X. maculatus backcross hybrids. Thus, CDKN2X may be a candidate for the tumor suppressor DIFF gene. Here we have sequenced CDKN2X in both Xiphophorus species and have characterized its expression in normal and melanotic tissues within control and backcross hybrid fish. A simultaneous expressional analysis of the Xmrk-2 tyrosine kinase receptor gene, which is strongly implicated in melanomagenesis in this system, was also performed. RT - PCR analyses revealed that both genes were highly expressed in melanomas. For CDKN2X, this result contrasts numerous findings in human tumors including human melanoma in which either CDKN2A (P16) deactivation or LOH was observed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.