ArticleOncogene1999
pRB is required for interferon-gamma-induction of the MHC class II abeta gene.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Construction of adenovirus vectors simultaneously expressing four multiplex, double-nicking guide RNAs of CRISPR/Cas9 and in vivo genome editing.Scientific reports · 2021Article
- Tumor Milieu Controlled by RB Tumor Suppressor.International journal of molecular sciences · 2020Review
- Cell Cycle and Beyond: Exploiting New RB1 Controlled Mechanisms for Cancer Therapy.Trends in cancer · 2019Review
- Beyond the Cell Cycle: Enhancing the Immune Surveillance of Tumors Via CDK4/6 Inhibition.Molecular cancer research : MCR · 2018Article
- MHC class II associated stomach cancer mutations correlate with lack of subsequent tumor development.Molecular and clinical oncology · 2017Article
- The RB tumor suppressor at the intersection of proliferation and immunity: relevance to disease immune evasion and immunotherapy.Cell cycle (Georgetown, Tex.) · 2015Review
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- Article
- Mutations and regulatory anomalies effecting tumor cell immune functions.Cancer immunology, immunotherapy : CII · 2004Review
- The class II transactivator requires brahma-related gene 1 to activate transcription of major histocompatibility complex class II genes.Molecular and cellular biology · 2002Article
- Interferon-gamma-induced chromatin remodeling at the CIITA locus is BRG1 dependent.The EMBO journal · 2002Article
- Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation.Molecular and cellular biology · 2001Article
- Article
- The retinoblastoma protein is an essential mediator that links the interferon-inducible 204 gene to cell-cycle regulation.Oncogene · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
pRB is required for IFN-gamma-induction of MHC class II in human tumor cell lines, providing a potential link between tumor suppressors and the immune system. However, other genes, such as cyclin D1, show pRB-dependency only in tumor cells, so by analogy, pRB may not be necessary for cII-regulation in normal cells. Here, we demonstrate that induction of the mouse MHC class II I-A heterodimer is normal in RB+/+ mouse embryonic fibroblasts (MEFs), but deficient in RB-/- MEFs. Inducibility is restored in RB-/- MEFs stably transfected with wild type RB cDNA or infected with an adenovirus expressing pRB. Thus, involvement of pRB in MHC class II expression is conserved in the mouse and is not an aberrant feature of tumorigenic, aneuploid, human tumor cells. Although cII genes are generally induced in a coordinate fashion, suggesting a common mechanism, we found that pRB was specifically required for induction of the Abeta, but not Aalpha or other MHC cII genes including Ebeta, Ii and H2-Malpha. Finally, IFN-gamma-induction of class II transactivator (CIITA), was pRB-independent, suggesting that pRB works downstream of this master-regulator of MHC class II expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.