ArticleMolecular and cellular biology1999
Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Is Male Infertility an Early Warning of More Serious Diseases?Endocrinology · 2026Review
- Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors.Genome medicine · 2024Article
- Transcriptome Studies Reveal theAnimals : an open access journal from MDPI · 2023Article
- Modeling primary ovarian insufficiency-associated loci in C. elegans identifies novel pathogenic allele of MSH5.Journal of assisted reproduction and genetics · 2022Article
- BRCA1 and BRCA2 Tumor Suppressor Function in Meiosis.Frontiers in cell and developmental biology · 2021Review
- BRCA1 and homologous recombination: implications from mouse embryonic development.Cell & bioscience · 2020Review
- Association of BRCA1 Mutations with Impaired Ovarian Reserve: Connection Between Infertility and Breast/Ovarian Cancer Risk.Journal of adolescent and young adult oncology · 2016Article
- Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice.The Journal of biological chemistry · 2014Article
- Human ovarian tissue cortex surrounding benign and malignant lesions.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing.PLoS genetics · 2013Article
- The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy.Cell & bioscience · 2013Article
- BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein.Cancer science · 2011Article
- BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability.Journal of molecular cell biology · 2011Review
- DNA mismatch repair and infertility.Current opinion in urology · 2010Review
- Association of BRCA1 mutations with occult primary ovarian insufficiency: a possible explanation for the link between infertility and breast/ovarian cancer risks.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2010Article
- BRCA1 deficient mouse models to study pathogenesis and therapy of triple negative breast cancer.Breast disease · 2010Review
- Preclinical mouse models for BRCA1-associated breast cancer.British journal of cancer · 2009Review
- Review
- Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects.Oncogene · 2006Review
- A molecular portrait of Arabidopsis meiosis.The arabidopsis book · 2006Article
Corrections and comments
- Correction · 2006-12-01Falsification/Fabrication of Data · Falsification/Fabrication of Image · Investigation by Company/Institution · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · NIH Finding of misconduct for Steven Anthony Leadon, 2/9/2006; See also https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259672/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019656/
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Authors and funding
6 authors.
Funding
Abstract
BRCA1 is a nuclear phosphoprotein expressed in a broad spectrum of tissues during cell division. The inheritance of a mutant BRCA1 allele dramatically increases a woman's lifetime risk for developing both breast and ovarian cancers. A number of mouse lines carrying mutations in the Brca1 gene have been generated, and mice homozygous for these mutations generally die before day 10 of embryonic development. We report here the survival of a small number of mice homozygous for mutations in both the p53 and Brca1 genes. The survival of these mice is likely due to additional unknown mutations or epigenetic effects. Analysis of the Brca1(-/-) p53(-/-) animals indicates that BRCA1 is not required for the development of most organ systems. However, these mice are growth retarded, males are infertile due to meiotic failure, and the mammary gland of the female mouse is underdeveloped. Growth deficiency due to loss of BRCA1 was more thoroughly examined in an analysis of primary fibroblast lines obtained from these animals. Like p53(-/-) fibroblasts, Brca1(-/-) p53(-/-) cells proliferate more rapidly than wild-type cells; however, a high level of cellular death in these cultures results in reduced overall growth rates in comparison to p53(-/-) fibroblasts. Brca1(-/-) p53(-/-) fibroblasts are also defective in transcription-coupled repair and display increased sensitivity to DNA-damaging agents. We show, however, that after continued culture, and perhaps accelerated by the loss of BRCA1 repair functions, populations of Brca1(-/-) p53(-/-) fibroblasts with increased growth rates can be isolated. The increased survival of BRCA1-deficient fibroblasts in the absence of p53, and with the subsequent accumulation of additional growth-promoting changes, may mimic the events that occur during malignant transformation of BRCA1-deficient epithelia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.