ArticleHeart (British Cardiac Society)1999
Serum total homocysteine and coronary heart disease: prospective study in middle aged men.
Article in Heart (British Cardiac Society), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 126 citations in OpenAlex.
- A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation.British journal of cancer · 2005Trial
- Involvements of Hyperhomocysteinemia in Neurological Disorders.Metabolites · 2021Review
- Low muscle mass in older men: the role of lifestyle, diet and cardiovascular risk factors.The journal of nutrition, health & aging · 2014Article
- Smokeless tobacco use: a risk factor for hyperhomocysteinemia in a Pakistani population.PloS one · 2013Article
- Homocysteine and asymmetric dimethylarginine in relation to B vitamins in elderly people.Wiener klinische Wochenschrift · 2011Article
- Association between serum homocysteine concentration with coronary artery disease in Iranian patients.ARYA atherosclerosis · 2011Article
- Biochemical risk indices, including plasma homocysteine, that prospectively predict mortality in older British people: the National Diet and Nutrition Survey of People Aged 65 Years and Over.The British journal of nutrition · 2010Article
- Homocysteine levels in chronic gastritis and other conditions: relations to incident cardiovascular disease and dementia.Digestive diseases and sciences · 2010Article
- Serum homocysteine level in patients with ankylosing spondylitis.Rheumatology international · 2009Article
- Hyperhomocysteinemia in ankylosing spondylitis: prevalence and association with clinical variables.Rheumatology international · 2008Article
- Hyperhomocysteinemia and recurrent carotid stenosis.BMC cardiovascular disorders · 2008Article
- Homocysteine lowering with folic acid and vitamin B supplements: effects on cardiovascular disease in older adults.Drugs & aging · 2006Review
- A continuous spectrophotometric assay for human cystathionine beta-synthase.Analytical biochemistry · 2005Article
- Homocysteine and atherothrombosis: diagnosis and treatment.Current atherosclerosis reports · 2003Review
- Homocysteine and coronary heart disease in the Caerphilly cohort: a 10 year follow up.Heart (British Cardiac Society) · 2001Article
- Homocysteine and ischaemic stroke in men: the Caerphilly study.Journal of epidemiology and community health · 2001Article
- Hyperhomocysteinemia and thrombosis.Lipids · 2001Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo examine the prospective relation between total homocysteine and major coronary heart disease events.
designA nested case-control study carried out within the British regional heart study, a prospective investigation of cardiovascular disease in men aged 40-59 years at entry. Serum total homocysteine concentrations were analysed retrospectively and blindly in baseline samples from 386 cases who had a myocardial infarct during 12.8 years of follow up and from 454 controls, frequency matched by age and town.
resultsGeometric mean serum total homocysteine was slightly higher in cases (14.2 micromol/l) than in controls (13.5 micromol/l), a proportional difference of 5.5% (95% confidence interval (CI) -0.02% to 10.8%, p = 0.06). Age adjusted risk of myocardial infarction increased weakly with log total homocysteine concentration; a 1 SD increase in log total homocysteine (equivalent to a 47% increase in total homo cysteine) was associated with an increase in odds of myocardial infarction of 1.15 (95% CI 1.00 to 1. 32; p = 0.05). The relation was particularly marked in the top fifth of the total homocysteine distribution (values >16.5 micromol/l), which had an odds ratio of 1.77 (95% CI 1.28 to 2.42) compared with lower levels. Adjustment for other risk factors had little effect on these findings. Total homocysteine concentrations more than 16.5 micromol/l accounted for 13% of the attributable risk of myocardial infarction in this study population. Serum total homocysteine among control subjects varied between towns and was correlated with town standardised mortality ratios for coronary heart disease (r = 0.43, p = 0.08).
conclusionsSerum total homocysteine is prospectively related to increased coronary risk and may also be related to geographical variation in coronary risk within Britain. These results strengthen the case for trials of total homocysteine reduction with folate.
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